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Late stage assay provider results from the probe development effort to identify inhibitors of PME-1: ABHD10 inhibitor LC-MS/MS-based cell-based ABPP-SILAC assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of PrCP in mouse plasma assessed as angiotensin 3 cleavage by whole serum shift assay
Assay data:10 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse PrCP
Assay data:22 Active, 8 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 22 Tested
Inhibition of mouse PrCP in qd for 2 days po dosed established diet-induced obese C57BL/6 mouse heat inactivated plasma
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PrCP-mediated conversion of Ang3 to Ang(2-7) in mouse plasma
Assay data:15 Active, 15 Activity ≤ 1 µM, 16 Tested
Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay
Assay data:17 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Late stage assay provider results from the probe development effort to identify inhibitors of diacylglycerol lipase, beta (DAGLb): LCMS-based animal-based Activity-Based Protein Profiling (ABPP) MudPIT selectivity analysis
Late stage assay provider results from the probe development effort to identify inhibitors of diacylglycerol lipase, beta (DAGLb): LCMS-based animal-based Activity-Based Protein Profiling (ABPP) MudPIT selectivity analysis for ABHD6
Late stage assay provider results from the probe development effort to identify inhibitors of diacylglycerol lipase, beta (DAGLb): LCMS-based cell-based Activity-Based Protein Profiling (ABPP) SILAC selectivity analysis for ABHD6
Inhibition of mouse PrCP in 3 mg/kg, po administered qd for 2 days established diet-induced obese C57BL/6 mouse heat inactivated plasma
Late stage assay provider results from the probe development effort to identify inhibitors of PME-1: LC-MS/MS-based cell-based ABPP-SILAC assay
Late stage assay provider results from the probe development effort to identify inhibitors of pPAFAH: LC-MS/MS-based biochemical ABPP-MudPIT assay to determine selectivity of test compounds in the mouse brain membrane proteome
Inhibition of PrCP in mouse plasma assessed as angiotensin 3 cleavage
Assay data:16 Active, 14 Activity ≤ 1 µM, 18 Tested
Assay data:6 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of mouse PrCP by FRET in presence of 1% mouse serum albumin
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Inhibition of mouse PrCP by FRET
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Late stage assay provider results from the probe development effort to identify inhibitors of LYPLA1: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for anti-target ABHD11
Late stage assay provider results from the probe development effort to identify inhibitors of PAFAH2: LC-MS-based cell-based SILAC Activity-Based Protein Profiling (ABPP) for PAFAH2
Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA1: LCMS-based Activity-Based Protein Profiling (ABPP) SILAC selectivity analysis in vitro
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
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