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Activity of human recombinant UGT2B17 expressed in insect cells assessed as enzyme-mediated N-carbamoyl glucuronide formation
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activity of human recombinant UGT2B17 expressed in insect cells assessed as enzyme mediated glucuronidation in presence of 5 to 35 uM androsterone by LC-MS/MS method
Drug metabolism assessed as recombinat UGT2B17 (unknown origin) -mediated dextrophan-O-glucuronide formation
Drug metabolism assessed as human UGT2B17-mediated N-glucuronide-triclocarban formation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis
Drug metabolism assessed as human UGT2B17-mediated N'-glucuronide-triclocarban formation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis
Drug metabolism assessed as human UGT2B17-mediated glucuronidation expressed in baculovirus infected insect sf9 cells incubated for 5 mins prior to UDPGA addition measured after 5 to 30 mins by LC-UV analysis
Assay data:3 Tested
Drug metabolism assessed as recombinant human UGT2B17 assessed as O-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis
Drug metabolism assessed as recombinant human UGT2B17 assessed as N-glucuronidation at 100 uM incubated for 60 mins by LC-MS/MS analysis
Activity of human recombinant UGT2B17 expressed in baculovirus-infected insect cells assessed as enzyme-mediated glucuronidation per mg of protein after 10 mins in presence of UDPGA
Drug metabolism assessed as human recombinant UGT2B17-mediated (2S,3S,4S,5R,6S)-6-(2-(4-(4-(tert-butylcarbamoyl)-2-(2-chloro-4-cyclopropylphenylsulfonamido)phenoxy)-5-chloro-2-fluorophenyl)acetoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid formation at 10 uM after 30 mins by LC-MS/MS analysis
Activity of human recombinant UGT2B17 expressed in insect cells assessed as intrinsic clearance for enzyme-mediated N-carbamoyl glucuronide formation
Activity of human recombinant UGT2B17 expressed in insect cells assessed as intrinsic clearance for enzyme mediated glucuronidation per mg protein by LC-MS/MS method
Activity of human recombinant UGT2B17 expressed in insect cells assessed as enzyme-mediated N-carbamoyl glucuronide formation per mg protein
Activity of human recombinant UGT2B17 expressed in insect cells assessed as intrinsic clearance for enzyme-mediated N-carbamoyl glucuronide formation per mg protein
Activity of human UGT2B17 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated (2S,3S,4S,5R,6R)-6-((1-carboxy-2-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)phenyl)ethylthio)carbonylamino)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid formation at 20 uM after 4 hrs by radio-HPLC/LC-MS/MS analysis in presence of UDPGA
Activity of human UGT2B17 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated 2-mercapto-3-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)phenyl)propanoic acid formation at 20 uM after 4 hrs by radio-HPLC/LC-MS/MS analysis in presence of UDPGA
Activity of human UGT2B17 expressed in microsomes isolated from baculovirus infected insect cell assessed as enzyme-mediated (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(5-(4-((6-methoxy-1-methyl-1H-benzo[d]imidazol-2-yl)methoxy)benzyl)-2,4-dioxothiazolidin-3-yl)tetrahydro-2H-pyran-2-carboxylic acid formation at 20 uM after 4 hrs by radio-HPLC/LC-MS/MS analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2B17-mediated estradiol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2B17-mediated 13-epiestradiol-17-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
Drug metabolism assessed as recombinant human C-terminal His-tagged UGT2B17-mediated 13-epiestradiol-3-glucuronide formation at 200 uM after 15 to 60 mins by HPLC analysis in presence of UDPGA
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