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Inhibition of mouse recombinant C-terminal FLAG-tagged SMS2 expressed in mammalian expression system using C14-phosphatidylcholineD72 and C17-ceramide pre-incubated for 60 mins followed by incubation with substrate for 30 mins measured by RapidFire/MS assay
Assay data:15 Active, 14 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SMS2 in C57BL/6J mouse bone marrow derived macrophages after 17 hrs
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of SMS2 in C57BL/6J mouse bone marrow derived macrophages assessed as increase in [3H]-cholesterol efflux after 17 hrs by liquid scintillation analysis
Inhibition of SMS2 in HFD-induced obese C57BL/6J mouse liver tissue lysate using NBD-ceramide as substrate assessed as reduction in DAG synthesis preincubated for 30 mins followed by substrate addition and measured after 3 hrs by HPLC analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of SMS2 in MEF cells using C6-NBD-ceramide as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by HPLC analysis
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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