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Binding affinity to wild-type Plasmodium falciparum full length CDPK1 (M1 to S524 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Plasmodium falciparum PFCDPK1 at 10 uM
Assay data:2 Tested
Binding constant for PFCDPK1(P.falciparum) kinase domain
Assay data:20 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 72 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Plasmodium falciparum PFCDPK1 assessed as residual activity at 10 uM relative to control
MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound.
Assay data:400 Activity ≤ 1 µM, 400 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical screen of P. falciparum CDPK1
Assay data:181 Active, 181 Activity ≤ 1 µM, 13451 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Plasmodium falciparum recombinant CDPK1 expressed in Escherichia coli expression system after 1 hr in presence of [gamma33P]ATP by scintillation proximity assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Plasmodium falciparum recombinant His-tagged CDPK1 expressed in Escherichia coli BL21(DE3) after 1 hr in presence of [gamma33P]ATP by scintillation proximity assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to wild-type Plasmodium falciparum full length CDPK1 (M1 to S524 residues) expressed in mammalian expression system assessed as residual binding at 1 uM by Kinomescan method relative to control
Binding affinity to wild-type Plasmodium falciparum full length CDPK1 (M1 to S524 residues) expressed in HEK293 cells at 1 uM by Kinomescan method relative to control
Binding affinity to wild-type Plasmodium falciparum 3D7 full length CDPK1 (M1 to S524 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control
Binding affinity to wild-type Plasmodium falciparum full length CDPK1 (M1 to S524 residues) expressed in mammalian expression system assessed as remaining unbound target protein level at 1000 nM by Kinomescan method relative to control
Inhibition of wild-type Plasmodium falciparum isolate 3D7 full length CDPK1 (M1 to S524 residues) expressed in mammalian expression system assessed as residual activity at 1 uM by Kinomescan method relative to control
Binding affinity to wild-type Plasmodium falciparum full length CDPK1 (M1 to S524 residues) expressed in mammalian expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control
Inhibition of Plasmodium falciparum CDPK1
Inhibition of wild-type Plasmodium falciparum full length CDPK1 (M1 to S524 residues) expressed in mammalian expression system assessed as residual activity at 10 uM by Kinomescan method relative to control
Inhibition of wild-type Plasmodium falciparum full length CDPK1 (M1 to S524 residues) expressed in mammalian expression system at 10 uM by Kinomescan method relative to control
Inhibition of wild-type Plasmodium falciparum full length CDPK1 (M1 to S524 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control
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