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Displacement of [125I]-(Glp1,Nle11,Try14)apelin-13 from recombinant rat EGFP-fused apelin receptor expressed in CHO cell membrane measured after 3 hrs
Assay data:9 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as receptor internalization at 100 uM after 20 mins by confocal microscopic analysis
Assay data:6 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as receptor internalization at 100 nM after 20 mins by confocal microscopic analysis
Assay data:1 Active, 1 Tested
Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as total receptor internalization at 10 to 100 uM after 20 mins by confocal microscopic analysis
Antagonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as inhibition of apelin-17-induced receptor internalization at 100 uM after 20 mins by confocal microscopic analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as inhibition of forskolin-induced cAMP production after 30 mins by fluorescence analysis
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Agonist activity at rat apelin receptor expressed in CHO cell membranes coexpressing EGFP assessed as inhibition of forskolin-induced cAMP production after 30 mins by fluorescence analysis relative to control
Assay data:4 Tested
Displacement of [125I]-pyr-1-apelin-13 from rat C-terminal EGFP-tagged APJ receptor expressed in CHO cell membranes after 3 hrs by Wallac gamma counting
Assay data:16 Active, 15 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
Agonist activity at rat APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by HTRF assay
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Displacement of [125I]-pyr-1-apelin-13 from EGFP tagged rat apelin receptor expressed in CHO cell membrane incubated for 3 hrs by gamma counter analysis
Assay data:13 Active, 8 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
Displacement of [125I]-pE13F from rat EGFP-tagged APJ receptor stably expressed in CHO cell membrane measured after 1 hr
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at rat APJ receptor stably expressed in CHO cell membranes in presence of [35S]GTPgammaS by scintillation proximity assay
Assay data:23 Active, 3 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested
Agonist activity at rat APJ receptor stably expressed in CHO cell membranes assessed as efficacy in presence of [35S]GTPgammaS by scintillation proximity assay
Assay data:22 Tested
Displacement of [125I]-pyr-1-apelin-13 from EGFP-tagged wild-type rat apelin receptor expressed in CHO cell membranes by gamma counting method
Assay data:25 Active, 11 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Agonist activity at APJ receptor in rat NRK-52E cells assessed as effect on cAMP accumulation incubated for 1 hr by cAMP-Glo assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay
Assay data:21 Active, 16 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Agonist activity at rat APJ receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 1 hr by TR-FRET assay
Assay data:15 Active, 5 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Agonist activity at rat APJ receptor expressed in HEK293T cells assessed as compound stimulated inhibition of forskolin stimulated cAMP production incubated for 30 mins by HTRF assay
Assay data:17 Active, 10 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 18 Tested
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