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SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 2
Assay data:8 Active, 1 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR compounds for Rab7 project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 2
Assay data:14 Active, 4 Activity ≤ 1 µM, 25 Tested
SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1
Assay data:10 Active, 10 Activity ≤ 1 µM, 27 Tested
SAR compounds for Rab7 project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1
Assay data:12 Active, 11 Activity ≤ 1 µM, 27 Tested
SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer
Assay data:23 Active, 25 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer
Assay data:11 Active, 26 Tested
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer
Assay data:5 Active, 5 Tested
Dose Response of compounds with constant GTP under the condition of nascent nucleotide depletion and Mg buffer
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype
Assay data:13 Active, 5 Activity ≤ 1 µM, 51 Tested
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype
Assay data:2 Active, 1 Activity ≤ 1 µM, 42 Tested
Additional SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
Assay data:3 Active, 42 Tested
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
Assay data:24 Active, 4 Activity ≤ 1 µM, 92 Tested
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein
Assay data:32 Active, 1 Activity ≤ 1 µM, 92 Tested
Oxadiazole SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
Assay data:37 Active, 7 Activity ≤ 1 µM, 51 Tested
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype
Assay data:38 Active, 7 Activity ≤ 1 µM, 1270 Tested
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant
Assay data:43 Active, 5 Activity ≤ 1 µM, 1269 Tested
Activator binding kinetics on Ras and Ras-related GTPases, specifically Cdc42_act (activated mutant)
Assay data:1 Active, 1 Tested
Activator binding kinetics on Ras and Ras-related GTPases, specifically Cdc42_wt
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