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Binding affinity to APC (unknown origin) assessed as dissociation constant by ITC analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to APC (unknown origin) assessed as inhibition constant by ITC analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of APC (303 to 739 residues) (unknown origin) assessed as inhibition constant preincubated for 60 mins followed by substrate addition and measured after 60 mins using Ac-GGGGEQLAINELISDGK-FITC as substrate by fluorescence polarization assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 6 Tested
Inhibition of APC (303 to 739 residues) (unknown origin) preincubated for 60 mins followed by substrate addition and measured after 60 mins using Ac-GGGGEQLAINELISDGK-FITC as substrate by fluorescence polarization assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested
Wnt APC Inhibition Assay from US Patent US10071086: "1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof"
Assay data:100 Active, 1 Activity ≤ 1 nM, 85 Activity ≤ 1 µM, 104 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human APC using pyroGlu-Pro-Arg-p-nitroaniline-HCl as substrate measured after 5 mins by plate reader analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human NTPDase-2 expressed in CHO-K1 cells in presence of DNA/LTX mixture
Inhibition of human NTPDase 2 expressed in human COS7 cells using ATP as substrate at 50 uM incubated for 5 mins followed by substrate addition and measured after 30 mins by capillary electrophoresis method
Inhibition of human NTPDase2 expressed in green monkey Cos-7 cells using ATP as substrate preincubated for 3 mins followed by substrate addition by malachite green reagent based assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of NTPDase 2 (unknown origin) expressed in CHO cells using ATP as substrate preincubated for 1 hr followed by substrate addition and measured after 50 mins by PiColorLock gold reagent based colorimetric assay
Assay data:3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to APC (unknown origin) assessed as inhibition of APC-Asef protein-protein interaction after 2 hrs by gel electrophoresis analysis
Assay data:1 Active, 1 Tested
Binding affinity to APC (unknown origin) by isothermal titration calorimetry assay
Binding affinity to APC (unknown origin) assessed as inhibition of APC-Asef protein-protein interaction after 2 hrs by fluorescence polarization immunoassay
Assay data:18 Active, 2 Activity ≤ 1 µM, 25 Tested
Inhibition of human APC incubated for 20 mins by fluorescence based assay
SummaryRelated BioAssays by Target
Inhibition of human NTPDase 2 expressed in CHO cells using ATP as substrate preincubated for 1 hr followed by substrate addition and measured after 50 mins by colorimetric assay
Inhibition of human NTPdase-2 expressed in COS7 cell membranes at 100 uM using ATP as substrate preincubated for 3 mins followed by susbtrate addition and measured after 10 mins by malachite green dye based method
Assay data:4 Active, 6 Tested
Inhibition of human NTPDase2 expressed in African green monkey COS7 cell membrane fraction using ATP as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by malachite green reagent-based assay
Assay data:14 Tested
Binding affinity to serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C in human INA-6 cells after 3 hrs by nanoLC-MS/MS method
Assay data:2 Active, 2 Tested
Binding affinity to serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B in human INA-6 cells after 3 hrs by nanoLC-MS/MS method
Activation of human NTPDase2 using ATP as substrate preincubated for 3 mins followed by substrate addition measured after 10 mins by malachite green reagent-based assay relative to control
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