Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of FAK (unknown origin)
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CHK1 (unknown origin) at 10 uM by biochemical hotspot kinase assay
Assay data:1 Tested
Inhibition of CDK1/cyclin E (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of CDK1/cyclin B (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of GSK3beta (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of AKT1 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of TAK1 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of RIPK2 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of c-RAF (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of EGFR (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of human EGFR L858R mutant (669 to 1210 residues) expressed in Sf21 insect cells using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate at 10 uM incubated for 60 mins relative to control
Inhibition of C-terminal His6 tagged human full length CDK1/N-terminal GST-tagged human full length Cyclin B expressed in baculovirus infected Sf21 cells using 5-FAM-QSPKKG-CONH2 as substrate at 10 uM incubated for 60 mins in presence of ATP relative to control
Inhibition of human EGFR L858R mutant (669 to 1210 residues) expressed in Sf21 insect cells using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate incubated for 60 mins
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of C-terminal His6 tagged human full length CDK1/N-terminal GST-tagged human full length Cyclin B expressed in baculovirus infected Sf21 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins in presence of ATP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of TP53 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
Assay data:2 Tested
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of PUMA mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of p21 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of MDM2 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of p53 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
Inhibition of MDM2 in human MV4-11 cells assessed as upregulation of TP53 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on