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Binding affinity towards human ESR2 in an in vitro cell free assay measured by fluorescence polarization method
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 287 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TRKB (unknown origin) using TK as substrate in presence of ATP incubated for 40 mins by HTRF KinEASE assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of TRKC (unknown origin) using TK as substrate in presence of ATP incubated for 40 mins by HTRF KinEASE assay
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of LCK (unknown origin) upto 10000 nM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at CCR2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of GSK3beta (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of LYN (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of LCK (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of RET (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of EGFR (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of VEGFR3 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of human EGFR L858R mutant (669 to 1210 residues) expressed in Sf21 insect cells using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate at 10 uM incubated for 60 mins relative to control
Inhibition of human EGFR L858R mutant (669 to 1210 residues) expressed in Sf21 insect cells using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate incubated for 60 mins
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of EGFR (unknown origin) using (Glu, Tyr) 4:1 as substrate incubated for [gamma-32P]-ATP incubated for 60 mins by scintillation counter analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human GST-tagged DYRK1A expressed in Escherichia coli using Woodtide as substrate in presence of [gamma-33P] ATP incubated for 30 mins by scintillation counter analysis
Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system by ELISA
Assay data:22 Active, 22 Activity ≤ 1 µM, 31 Tested
Inhibition of EGFR T790M mutant (unknown origin) expressed in baculovirus expression system by ELISA
Assay data:8 Active, 9 Activity ≤ 1 µM, 9 Tested
Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system by ELISA
Assay data:31 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 31 Tested
Inhibition of EGFR phosphorylation in EGF-stimulated human NCI-H1975 cells harboring EGFR L858R/T790M double mutant at 0.1 to 100 nM and measured after 2 hrs by Western blot analysis
Assay data:2 Tested
Inhibition of EGFR phosphorylation in EGF-stimulated human NCI-H1975 cells harboring EGFR L858R/T790M double mutant at 10 nM and measured after 2 hrs by Western blot analysis
Assay data:3 Active, 3 Tested
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