Related BioAssays, by Gene Interaction (List) for PubChem BioAssay (Se - PubChem BioAssay - NCBI

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Select item 20603241.

Source:: National Center for Advancing Translational Sciences (NCATS)

Deposit Date:: 2025/01/22
Hold-until Date:: 2026/01/21

AID:: 2060324

Select item 20603232.

Source:: National Center for Advancing Translational Sciences (NCATS)

Deposit Date:: 2025/01/22
Hold-until Date:: 2026/01/21

AID:: 2060323

Select item 20603223.

Source:: National Center for Advancing Translational Sciences (NCATS)

Deposit Date:: 2025/01/22
Hold-until Date:: 2026/01/21

AID:: 2060322

Select item 19635854.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:70 Active, 12 Activity ≤ 1 µM, 9667 Tested

AID:: 1963585

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19635845.

p53 small molecule agonists, cell-based qHTS assay: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested

AID:: 1963584

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19635836.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:103 Active, 14 Activity ≤ 1 µM, 9667 Tested

AID:: 1963583

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19635827.

p53 small molecule agonists, cell-based qHTS assay

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested

AID:: 1963582

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19635788.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:27 Active, 44 Activity ≤ 1 µM, 9667 Tested

AID:: 1963578

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19635779.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:43 Active, 55 Activity ≤ 1 µM, 9667 Tested

AID:: 1963577

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project

Select item 196345210.

Source:: National Center for Advancing Translational Sciences (NCATS)

Deposit Date:: 2024/06/03
Hold-until Date:: 2025/05/15

AID:: 1963452

Select item 196104811.

Inhibition of tubulin polymerization (unknown origin) by fluorescence assay relative to control

Source:: ChEMBL

Protein Targets:: Tubulin alpha-1A chain; ...
Total:: 15

Assay data:2 Tested

AID:: 1961048

Summary PubMed Citation Related BioAssays by Target

Select item 196091012.

Inhibition of WEE1 (unknown origin) at 10 uM by biochemical hotspot kinase assay

Source:: ChEMBL

Protein Target:: Wee1-like protein kinase

Assay data:1 Tested

AID:: 1960910

Summary PubMed Citation Related BioAssays by Target

Select item 196090113.

Inhibition of CHK2 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase Chk2

Assay data:1 Tested

AID:: 1960901

Summary PubMed Citation Related BioAssays by Target

Select item 196090014.

Inhibition of CHK1 (unknown origin) at 10 uM by biochemical hotspot kinase assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase Chk1

Assay data:1 Tested

AID:: 1960900

Summary PubMed Citation Related BioAssays by Target

Select item 196088215.

Inhibition of CDK1/cyclin E (unknown origin) at 10 uM by biochemical hotspot kinase assay

Source:: ChEMBL

Protein Targets:: Cyclin-dependent kinase 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1960882

Summary PubMed Citation Related BioAssays by Target

Select item 196088116.

Inhibition of CDK1/cyclin B (unknown origin) at 10 uM by biochemical hotspot kinase assay

Source:: ChEMBL

Protein Targets:: Cyclin-dependent kinase 1; ...
Total:: 4

Assay data:1 Tested

AID:: 1960881

Summary PubMed Citation Related BioAssays by Target

Select item 196087917.

Inhibition of ERK2 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 1

Assay data:1 Tested

AID:: 1960879

Summary PubMed Citation Related BioAssays by Target

Select item 196087418.

Inhibition of AKT1 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control

Source:: ChEMBL

Protein Target:: RAC-alpha serine/threonine-protein kinase

Assay data:1 Tested

AID:: 1960874

Summary PubMed Citation Related BioAssays by Target

Select item 196086619.

Inhibition of c-Src (unknown origin) at 10 uM by biochemical hotspot kinase assay

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase Src

Assay data:1 Tested

AID:: 1960866

Summary PubMed Citation Related BioAssays by Target

Select item 196085420.

Inhibition of EGFR (unknown origin) at 10 uM by biochemical hotspot kinase assay

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Tested

AID:: 1960854

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (337)
BioAssays with protein sequences specified as targets

BioActivity

Chemical Probes (8)
BioAssays with compounds reported as validated chemical probes

Active Compounds (18,747)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1,450)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (10,266)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (33)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (15,099)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (44)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
On Hold (4)
On hold BioAssays

Assay Project (241)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (38,800)
BioAssays extracted from the literature
NIH MLP (270)
BioAssays deposited by the NIH Molecular Libraries Program
Other (1,995)
BioAssays deposited by other experimentalists

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