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Stability in presence of 0.1 mg/ml pronase in 100 mM pH 7.8 ammonium bicarbonate buffer at 37 degC assessed as compound degradation after 18 hrs by HPLC method
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Bactericidal activity against Escherichia ATCC 25922 assessed as reduction bacterial colony count at 25 ug/ml measured after 10 mins to 2 hrs by colony count based time-kill assay
Assay data:1 Tested
SummaryPubMed Citation
Bactericidal activity against Escherichia ATCC 25922 at 25 and 50 ug/ml measured after 1 hr by colony count based time-kill assay
Assay data:1 Active, 1 Tested
Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 33592 at 12.5 to 50 ug/ml measured after 30 mins by colony count based time-kill assay
Induction of cell aggregation of Escherichia ATCC 25922 at 10 ug/ml incubated for 2 hrs by DAPI and propidium iodide staining based fluorescence microscopy
Induction of membrane disruption in Escherichia ATCC 25922 at 10 ug/ml incubated for 2 hrs by DAPI and propidium iodide staining based fluorescence microscopy
Induction of membrane disruption in methicillin-resistant Staphylococcus aureus ATCC 33592 at 10 ug/ml incubated for 2 hrs by DAPI and propidium iodide staining based fluorescence microscopy
Cytotoxicity against mouse N2a cells assessed as cell viability after 12 hrs by MTT assay
Assay data:2 Tested
Induction of hemolysis in human RBCs incubated for 1 hr
Assay data:13 Tested
Antimicrobial activity against Escherichia ATCC 25922 after 16 hrs
Assay data:16 Tested
Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 16 hrs
Antimicrobial activity against Enterococcus faecalis ATCC 700802 after 16 hrs
Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis RP62A after 16 hrs
Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 after 16 hrs
Retention time of the compound by HPLC analysis
Assay data:30 Tested
Proteolytic stability assessed as alpha chymotrypsin (unknown origin)-mediated compound degradation by measuring compound remaining after 4 days by RP-HPLC analysis
Assay data:4 Tested
Proteolytic stability assessed as alpha chymotrypsin (unknown origin)-mediated compound degradation after 24 hrs by RP-HPLC analysis
Assay data:2 Active, 2 Tested
Proteolytic stability assessed as trypsin (unknown origin)-mediated compound degradation by measuring compound remaining after 4 days by RP-HPLC analysis
Assay data:1 Active, 4 Tested
Proteolytic stability assessed as trypsin (unknown origin)-mediated compound degradation after 36 hrs by RP-HPLC analysis
Stability in human plasma assessed as compound degradation after 12 hrs by RP-HPLC analysis
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