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Inhibition of UGT (unknown origin) preincubated for 10 mins followed by substrates addition measured after 10 mins by LC-MS analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B15 assessed as UGT2B15 mediated glucuronidation by measuring glucuronide conjugation at 10 uM and measured after 30 mins by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B7 assessed as UGT2B7 mediated glucuronidation by measuring glucuronide conjugation at 10 uM and measured after 30 mins by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B15 assessed as UGT2B15 mediated glucuronidation by measuring glucuronide conjugation at 10 uM and measured after 15 mins by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B7 assessed as UGT2B7 mediated glucuronidation by measuring glucuronide conjugation at 10 uM and measured after 15 mins by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B15 assessed as UGT2B15 mediated glucuronidation by measuring glucuronide conjugation at 10 uM and measured immediately by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B7 assessed as UGT2B7 mediated glucuronidation by measuring glucuronide conjugation at 10 uM and measured immediately by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B15 assessed as UGT2B15 mediated glucuronidation by measuring parent compound remaining at 10 uM and measured after 30 mins by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B7 assessed as UGT2B7 mediated glucuronidation by measuring parent compound remaining at 10 uM and measured after 30 mins by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B15 assessed as UGT2B15 mediated glucuronidation by measuring parent compound remaining at 10 uM and measured after 15 mins by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B7 assessed as UGT2B7 mediated glucuronidation by measuring parent compound remaining at 10 uM and measured after 15 mins by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B15 assessed as UGT2B15 mediated glucuronidation by measuring parent compound remaining at 10 uM and measured immediately by HPLC-MS/MS analysis
Drug metabolism in baculovirus insect cell microsomes expressing human UGT2B7 assessed as UGT2B7 mediated glucuronidation by measuring parent compound remaining at 10 uM and measured immediately by HPLC-MS/MS analysis
Binding affinity to UGT2B7 (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Metabolic stability in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 60 mins in presence of NADPH
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Metabolic stability in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 30 mins in presence of NADPH
Metabolic stability in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 15 mins in presence of NADPH
Metabolic stability assessed as human UGT-mediated metabolism by measuring half life by phase II UGT conjugation assay
Metabolic stability in human assessed as UGT-mediated metabolism by measuring half life
UDP-glucuronosyltransferase Activity Assay from Article 10.3109/14756366.2010.518965: "The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors."
Assay data:2 Active, 20 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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