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Induction of SREBP degradation expressed in human HEK293T cells assessed as increase in SREBP ubiquitination at 10 uM after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of SREBP degradation in human HepG2 cells at 10 uM preincubated with MG-132 for 1 hr followed by compound additon and measured after 4 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of SREBP degradation in human HepG2 cells at 10 uM preincubated with cycloheximide for 1 hr followed by compound additon by Western blot analysis
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells assessed as reduction in mature SREBP protein level at 1 uM after 24 hrs by Western blotting analysis
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells assessed as reduction in precursor SREBP protein level at 1 uM after 24 hrs by Western blotting analysis
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells assessed as reduction in mature SREBP protein level at 5 uM after 24 hrs by Western blotting analysis
Assay data:2 Active, 2 Tested
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells assessed as reduction in precursor SREBP protein level at 5 uM after 24 hrs by Western blotting analysis
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells by luciferase reporter assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SREBP (unknown origin) expressed in CHO-K1 cells at 5 uM by luciferase reporter assay
Assay data:18 Active, 28 Tested
Inhibition of SREBP (unknown origin) expressed in HEK293 cells assessed as reduction in LDLr promotor activity after 24 hrs by luciferase reporter assay
Assay data:5 Active, 13 Tested
Inhibition of SREBP1c in mouse 3T3L1 preadipocytes assessed as downregulation of SCD-1 mRNA expression at 50 to 100 uM after 8 days by qRT-PCR analysis
Inhibition of SREBP1c in mouse 3T3L1 preadipocytes assessed as downregulation of FAS mRNA expression at 50 to 100 uM after 8 days by qRT-PCR analysis
Inhibition of SREBP1c in mouse 3T3L1 preadipocytes at 50 to 100 uM after 8 days by Western blot analysis
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