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Inhibition of human LRP6-DKK1 interaction by binding to LRP6 incubated for 1 hr by SPR analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of sclerostin binding to LRP5/6 in mouse ST-2 cells assessed as reduction in sclerostin-induced inhibition of Wnt-mediated signaling activity at 3 to 10 uM after 3 days by alkaline phosphatase dye based microscopic analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of sclerostin binding to LRP6 (unknown origin) expressed in rat MC3T3-E1 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in sclerostin-induced inhibition of Wnt3a activation by measuring increase in luciferase activity after 24 hrs by dual-luciferase reporter gene assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of sclerostin binding to LRP6 (unknown origin) expressed in rat MC3T3-E1 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in sclerostin-induced inhibition of Wnt3a activation by measuring luciferase activity at 0.3 uM after 24 hrs by dual-luciferase reporter gene assay (Rvb = 100 +/- 2.6%)
Assay data:5 Tested
Inhibition of sclerostin binding to human ALP-fused LRP5 at 50 uM using alkaline phosphatase as substrate pretreated for 2 hrs followed by substrate addition measured after 25 mins by ELISA relative to control
Inhibition of sclerostin binding to LRP6 (unknown origin) expressed in rat MC3T3-E1 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in sclerostin-induced inhibition of Wnt3a activation by measuring luciferase activity at 3 uM after 24 hrs by dual-luciferase reporter gene assay (Rvb = 100 +/- 3.1%)
Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned medium
Binding affinity to LRP6 in human SH-SY5Y cells assessed as inhibition of DKK1/LRP6 interaction-mediated tau phosphorylation at serine 396 at 10 uM incubated for 1 hr using compound pre-treated DKK1 conditioned media by Western blot analysis
Assay data:3 Active, 3 Tested
Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned media after 2 hrs by fluorescence microscopic analysis
Assay data:12 Active, 12 Tested
Binding affinity to LRP6 in human SH-SY5Y cells assessed as DKK1/LRP6 interaction-mediated increase in beta-catenin level at 10 uM incubated for 1 hr using compound pre-treated DKK1 conditioned media by Western blot analysis
Assay data:11 Active, 11 Tested
Inhibition of DKK1-LRP6 interactions in mouse cortical neurons assessed as inhibition of prostaglandinJ2-induced tau phosphorylation at Ser396 residue at 10 uM for 1 hr by western bloting
Assay data:9 Active, 9 Tested
Inhibition of DKK1/LRP6 (unknown origin) expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction at 100 uM after 2 hrs by immunofluorescence method
Assay data:19 Active, 19 Tested
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