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Binding affinity to N-terminal His-tagged full length human PSD-95alpha PDZ2 domain (155 to 249 residues) without exon 4b expressed in Escherichia coli BL21(DE3)pLysS by isothermal titration colorimetric method
Assay data:2 Tested
SummaryRelated BioAssays by Target
Ratio of Kd for N-terminal His-tagged full length human PSD-95alpha PDZ2 domain (155 to 249 residues) without exon 4b expressed in Escherichia coli BL21(DE3)pLysS by isothermal titration colorimetric method to Ki for N-terminal His-tagged full length human PSD-95alpha PDZ2 domain (155 to 249 residues) without exon 4b expressed in Escherichia coli BL21(DE3)pLysS by fluorescence polarization assay
Inhibition of rat PSD-95 PDZ1 domain interaction with mouse 5HT2A receptor after 18 hrs by pull down assay
Assay data:1 Tested
Displacement of Cy5-CRIPT from N-terminal His-tagged human full length PSD-95alpha PDZ3 domain (309 to 401 residues) without exon 4b expressed in Escherichia coli BL21(DE3)pLysS by fluorescence polarization assay
Assay data:3 Tested
Displacement of Cy5-GluN2B from N-terminal His-tagged full length human PSD-95alpha PDZ2 domain (155 to 249 residues) without exon 4b expressed in Escherichia coli BL21(DE3)pLysS by fluorescence polarization assay
Assay data:7 Tested
Displacement of Cy5-GluN2B from N-terminal His-tagged human full length PSD-95alpha PDZ1 domain (61 to 151 residues) without exon 4b expressed in Escherichia coli BL21(DE3)pLysS by fluorescence polarization assay
Assay data:5 Tested
Potency index, ratio of indole 1 Ki to compound Ki for N-terminal His-tagged full length human PSD-95alpha PDZ2 domain (155 to 249 residues) without exon 4b expressed in Escherichia coli BL21(DE3)pLysS
Binding affinity to PSD-95 PDZ1 domain (unknown origin) expressed in Escherichia coli BL21 at 1 mM by 1H-15N HSQC NMR analysis
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to PSD-95 PDZ2 domain (unknown origin) expressed in Escherichia coli BL21 at 1 mM by 1H-15N HSQC NMR analysis
Binding affinity to Swiss mouse brain PSD95 domain assessed as inhibition of PSD95-5-HT2A receptor C-terminal decapeptide interaction after overnight incubation by chemiluminescence assay
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant 15N-labelled PSD95-PDZ1 domain expressed in Escherichia coli BL21 assessed as chemical shift perturbation by NMR spectra analysis
Assay data:3 Active, 8 Tested
Inhibition of PSD-95 PDZ2 domain-GluN2B interaction expressed in COS7 cells transfected with pGFP2-PDZ2 and pRluc-N2B at 100 uM by BRET assay
Assay data:1 Active, 1 Tested
Inhibition of PSD-95 PDZ2 domain-GluN2B interaction expressed in COS7 cells transfected with pGFP2-PDZ2 and pRluc-N2B at 50 to 1000 uM by BRET assay
Assay data:1 Active, 7 Tested
Inhibition of PSD-95 PDZ2 domain-GluN2B interaction expressed in COS7 cells transfected with pGFP2-PDZ2 and pRluc-N2B at 500 uM by BRET assay
Assay data:6 Active, 12 Tested
Inhibition of PSD-95 PDZ2 domain by competitive fluorescence polarization assay
Assay data:22 Active, 4 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Ratio of Ki for PSD-95 PDZ2 domain to Ki for PSD-95 PDZ3 domain
Assay data:29 Tested
Inhibition of PSD-95 PDZ3 domain by competitive fluorescence polarization assay
Assay data:4 Active, 29 Tested
Binding affinity to human PSD95 domain PDZ1-2 expressed in Escherichia coli BL21-DE3 by fluorescence polarization assay
Assay data:2 Active, 3 Tested
Binding affinity to human PSD95 domain PDZ3 expressed in Escherichia coli BL21-DE3 by fluorescence polarization assay
Assay data:4 Active, 17 Tested
Binding affinity to human PSD95 domain PDZ2 expressed in Escherichia coli BL21-DE3 by fluorescence polarization assay
Assay data:15 Active, 3 Activity ≤ 1 µM, 33 Tested
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