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% Enzyme Activity of Caspase 11 in the Reaction Biology protease panel at 1.0 M
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
% Enzyme Activity of Caspase 5 in the Reaction Biology protease panel at 1.0 M
% Enzyme Activity of Caspase 4 in the Reaction Biology protease panel at 1.0 M
Caspase Catalytic Activity Assay from Article 10.1016/j.chembiol.2017.02.003: "Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors."
Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Fluorometric Enzymatic Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:15 Active, 9 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
In Vitro Inhibitory Activity of Caspase from US Patent US10167313: "Selective caspase inhibitors and uses thereof"
Assay data:18 Active, 17 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Caspase Inhibition Assay from Article 10.1021/jm0100537: "Potent and selective nonpeptide inhibitors of caspases 3 and 7."
Assay data:26 Active, 20 Activity ≤ 1 µM, 30 Tested
Fluorometric Assay from Article 10.1021/jm020230j: "Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design."
Assay data:42 Active, 34 Activity ≤ 1 µM, 43 Tested
Inhibition of Caspase 5 (unknown origin) at 10 uM
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Caspase 4 (unknown origin) at 10 uM
Inhibition of pyroptosis-inducing caspase-11 in LPS-primed immortalized mouse J744A.1 cells assessed as cell death at 5 uM by LDH assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of caspase-5 (unknown origin) at 10 uM
Inhibition of caspase-4 (unknown origin) at 10 uM
Inhibition of caspase5 (unknown origin) at 1 uM relative to control
Assay data:2 Tested
Activation of caspase cascade in human T47D cells using N-(Ac-DEVD)-N'-ethoxycarbonyl-R110 fluorogenic substrate incubated for 48 hrs by fluorescent plate reader based assay
Activation of caspase (unknown origin)
Inhibition of human recombinant caspase-5 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assay
Human Caspase 5 (C14: Caspase)
Assay data:3 Active, 3 Tested
Human Caspase 4 (C14: Caspase)
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