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Caspase Catalytic Activity Assay from Article 10.1016/j.chembiol.2017.02.003: "Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors."
Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Fluorometric Enzymatic Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:15 Active, 9 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
In Vitro Inhibitory Activity of Caspase from US Patent US10167313: "Selective caspase inhibitors and uses thereof"
Assay data:18 Active, 17 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Caspase Inhibition Assay from Article 10.1021/jm0100537: "Potent and selective nonpeptide inhibitors of caspases 3 and 7."
Assay data:26 Active, 20 Activity ≤ 1 µM, 30 Tested
Fluorometric Assay from Article 10.1021/jm020230j: "Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design."
Assay data:42 Active, 34 Activity ≤ 1 µM, 43 Tested
Inhibition of Caspase 5 (unknown origin) at 10 uM
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Caspase 4 (unknown origin) at 10 uM
Inhibition of caspase-5 (unknown origin) at 10 uM
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of caspase-4 (unknown origin) at 10 uM
Inhibition of caspase5 (unknown origin) at 1 uM relative to control
Assay data:2 Tested
Activation of caspase cascade in human T47D cells using N-(Ac-DEVD)-N'-ethoxycarbonyl-R110 fluorogenic substrate incubated for 48 hrs by fluorescent plate reader based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Activation of caspase (unknown origin)
Inhibition of human recombinant caspase-5 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assay
Human Caspase 5 (C14: Caspase)
Assay data:3 Active, 3 Tested
Human Caspase 4 (C14: Caspase)
Ratio of IC50 for human recombinant DTT-activated caspase-5 expressed in Escherichia coli preincubated for 15 mins followed by Ac-WEHD-AMC substrate addition to IC50 for human recombinant DTT-activated caspase-5 expressed in Escherichia coli preincubated for 45 mins followed by Ac-WEHD-AMC substrate addition
Assay data:1 Tested
Ratio of IC50 for human recombinant DTT-activated caspase-5 expressed in Escherichia coli preincubated for 15 mins followed by Ac-WEHD-AMC substrate addition to IC50 for human recombinant DTT-activated caspase-5 expressed in Escherichia coli preincubated for 30 mins followed by Ac-WEHD-AMC substrate addition
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 45 mins followed by substrate addition by fluorescence assay
Inhibition of human recombinant DTT-activated caspase-5 expressed in Escherichia coli using Ac-WEHD-AMC as substrate preincubated for 15 mins followed by substrate addition by fluorescence assay
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