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PRESTO-Tango GPCRome screening (LTB4R2B)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate by measuring efficacy at 20 uM measured after 90 mins by HTRF assay relative to CAY10583
Assay data:11 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
Assay data:9 Active, 4 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as IP-1 accumulation at >50 uM incubated for 90 mins by IP-one assay relative to basal level
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as IP-1 accumulation at >10 uM incubated for 90 mins by IP-one assay relative to basal level
Assay data:2 Active, 2 Tested
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay relative to CAY10583
Assay data:40 Tested
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
Assay data:40 Active, 32 Activity ≤ 1 µM, 51 Tested
Inhibition of human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as IP-1 accumulation at 50 uM incubated for 90 mins by IP-one assay relative to basal level
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation at 20 uM incubated for 90 mins by IP-one assay relative to basal level
Partial agonist activity at HA-epitope tagged human BLT2 expressed in CHOK1 cells assessed as induction of chemotactic motility incubated for 2 hrs by hematoxylin and eosin staining based optical microscopic method
Agonist activity at HA-epitope tagged human BLT2 expressed in CHOK1 cells assessed as induction of chemotactic motility incubated for 2 hrs by hematoxylin and eosin staining based optical microscopic method
Agonist activity at HA-epitope tagged human BLT2 expressed in CHOK1 cells assessed as induction of chemotactic motility at 300 nM incubated for 2 hrs by hematoxylin and eosin staining based optical microscopic method
Agonist activity at HA-epitope tagged human BLT2 expressed in CHOK1 cells assessed as induction of chemotactic motility at 100 nM incubated for 2 hrs by hematoxylin and eosin staining based optical microscopic method
Displacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting method
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Activity at human LTB4 receptor up to 10 uM
Mouse BLT2 receptor (Leukotriene receptors)
Human BLT2 receptor (Leukotriene receptors)
Assay data:9 Active, 9 Tested
Binding affinity to human leukotriene B4 receptor at 10 uM by radioligand binding assay
Inhibition of BLT2 (unknown origin) at 10 uM relative to control
Binding affinity to leukotriene B4 receptor (unknown origin) at 10 uM
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