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Protac activity at IAP/RIPK2 in human THP-1 cells assessed as degradation of RIPK2 measured after 18 hrs by capillary immunoassay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
PROTAC activity at CRBN/XIAP in human MCF7 cells assessed as protein abundance at 1 uM measured after 4 hrs by TMT-labeling based LC-MS/MS analysis
Binding affinity to CRBN/XIAP in human HEK293T cells assessed as ternary complex formation at 1 uM measured after 6 hrs by immunoprecipitation analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of XIAP degradation in human MCF7 cells transfected with CRBN siRNA at 0.01 to 1 uM measured after 18 hrs by western blot analysis
PROTAC activity at CRBN/XIAP in human MCF7 cells assessed as induction of XIAP degradation at 1 uM measured after 6 hrs in presence of proteasome inhibitor, MG132 by western blot analysis
PROTAC activity at CRBN/XIAP in human MCF7 cells assessed as induction of XIAP degradation at 0.1 uM measured within 1 hr by western blot analysis
PROTAC activity at CRBN/XIAP in human MCF7 cells assessed as induction of XIAP degradation at 0.1 to 10 uM measured after 18 hrs by western blot analysis
PROTAC activity at CRBN/XIAP in human MCF7 cells assessed as induction of XIAP degradation at 1 uM measured after 18 hrs by western blot analysis
Assay data:12 Tested
PROTAC activity at CRBN/XIAP in human MCF7 cells assessed as induction of XIAP degradation at 0.1 uM measured after 18 hrs by western blot analysis
PROTAC activity at XIAP/ERalpha (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human XIAP BIR3 domain K299A mutant at 10 uM incubated for 2 hrs by SDS-PAGE analysis
Binding affinity to human XIAP BIR3 domain K297A mutant at 10 uM incubated for 2 hrs by SDS-PAGE analysis
Binding affinity to human XIAP BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21-Gold(DE3) pLysS cells at 10 uM incubated for 2 hrs by SDS-PAGE analysis
Binding affinity to human XIAP BIR3 domain K299A mutant assessed as change in melting temperature at 20 uM incubated for 2 hrs by SYPRO orange dye based fluorescence assay
Binding affinity to human XIAP BIR3 domain K297A mutant assessed as change in melting temperature at 20 uM incubated for 2 hrs by SYPRO orange dye based fluorescence assay
Assay data:2 Tested
Binding affinity to human XIAP BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21-Gold(DE3) pLysS cells assessed as change in melting temperature at 20 uM incubated for 2 hrs by SYPRO orange dye based fluorescence assay
Displacement of AVPI-biotin from human XIAP BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21-Gold(DE3) pLysS cells assessed as Kinact/Ki measured upto 40 mins by DELFIA
Displacement of AVPI-biotin from human XIAP BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21-Gold(DE3) pLysS cells incubated for 2 hrs by DELFIA
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Displacement of AVPI-biotin from human XIAP BIR3 domain (253 to 347 residues) expressed in Escherichia coli BL21-Gold(DE3) pLysS cells preincubated for 6 hrs followed by AVPI-biotin addition for 2 hrs by DELFIA
Induction of XIAP degradation in human MM1.S cells at 100 nM incubated for 3 hrs by diaPASEF-based analysis
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