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Selectivity interaction (Eurofins CEREP Diversity Profile (receptors and ion channels)) EUB0000279b PGR
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Progesteron receptor agonist/antagonist FRET assay, human recombinant) EUB0000877a PGR
Inhibition of Progesterone PR-B at 10.0 M in the Eurofins Panlabs Safety Screen
Activity against PROGEST/BO in the Eurofins Panlabs screen (BI) by Radioactive Assay
Agonist activity at Gal4DBD-fused PR LBD (unknown origin) transfected in luc2p-Gal4-HEK293 cells assessed as receptor transactivation at 10 uM incubated for 24 hrs by Bright-Glo luciferase reporter gene assay
Inhibition of PGR transcription in human MCF7 harboring ERalpha Y5337S mutant measured upto 96 hrs by qPCR analysis relative to control
Inhibition of PGR transcription in human MCF7 harboring wild type ERalpha measured upto 96 hrs by qPCR analysis relative to control
Activation of Gal-DBD and NHRLBD fused PR (unknown origin) transfected in African green monkey CV-1 cells by luciferase reporter assay
Assay data:3 Tested
Activation of GST-tagged Progesterone receptor (unknown origin) upto 100 uM by luminescence based assay
Assay data:2 Tested
Antagonist activity at PR (unknown origin)
Progesterone PR-B Eurofins Panlabs panel
Binding affinity towards human PGR in an in vitro assay with cellular components measured by scintillation counting
Assay data:87 Active, 51 Activity ≤ 1 µM, 927 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity towards human PGR in an in vitro cell free assay measured by fluorescence polarization method in vitro cell free assay
Assay data:15 Active, 5 Activity ≤ 1 µM, 357 Tested
Antagonist activity at human PGR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:29 Active, 4 Activity ≤ 1 µM, 850 Tested
Agonist activity at human PGR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:55 Active, 39 Activity ≤ 1 µM, 930 Tested
Antagonist activity at progesterone receptor (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Activation of human progesterone receptor transfected in human PC-3 cells incubated for 16 hrs by luciferase based analysis
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human PR-beta expressed in U2OS cells by PathHunter assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at human PR-alpha expressed in U2OS cells by PathHunter assay
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