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Inhibition of CCR8-mediated cell migration in CCL1-induced human PBMC preincubated for 1 hr followed by CCL1 addition measured after 4 hrs by cell counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CCR8-mediated calcium mobilization transfected in HEK293 cells assessed as CCL1-induced intracellular Ca2+ level by Fluo4 AM dye based assay
Inhibition of CCR8 (unknown origin)-mediated beta-arrestin downstream signalling in CCL1-induced CHO cells assessed as beta-lactamase level by Tango assay
Antagonist activity against CCR8 (unknown origin) expressed in CHO-K1 cells preincubated for 1 hr followed by CCL1 addition measured after 24 hrs by ONE-Glo assay
Assay data:32 Active, 1 Activity ≤ 1 nM, 50 Activity ≤ 1 µM, 50 Tested
Inhibition of CCR8 mutant (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Antagonist activity against CCR8 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity against CCR8 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
PRESTO-Tango GPCRome screening (CCR8)
SummaryRelated BioAssays by Target
Agonist activity at human CCR8 expressed in CHO-K1 cells at 20 uM by PathHunter beta-arrestin assay relative to control
Assay data:8 Tested
Antagonist activity at human CCR8 expressed in CHO-K1 cells by PathHunter beta-arrestin assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human CCR8 expressed in CHO-K1 cells at 20 uM by PathHunter beta-arrestin assay relative to control
Antagonist activity at human CCR8 receptor assessed as inhibition of CCL1-induced beta arrestin2 recruitment at 500 nM preincubated for 30 mins followed by CCL1 stimulation and measured after 90 to 180 mins by pathhunter assay
Antagonist activity at human CCR8 expressed in CHOK1 cells assessed as reduction in CCL1-induced beta-arrestin 2 recruitment incubated for 30 mins followed by CCL1 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
Antagonist activity at human CCR8 expressed in CHOK1 cells assessed as inhibition in CCL1-induced beta-arrestin 2 recruitment at 20 uM incubated for 30 mins followed by CCL1 addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay relative to control
Assay data:9 Tested
Antagonist activity at CCR8 (unknown origin) at 10 uM
Assay data:3 Tested
Antagonist activity at CCR8 (unknown origin)
Agonist activity at CCR8 (unknown origin)
Mouse CCR8 (Chemokine receptors)
Assay data:2 Active, 2 Tested
Human CCR8 (Chemokine receptors)
Assay data:6 Active, 6 Tested
Inhibition of CCR8 (unknown origin) at 10 uM relative to control
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