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Inhibition of Serratia marcescens IMP-1 expressed in Escherichia coli BL21 (DE3) using cephalothin as substrate preincubated for 5 mins followed by substrate addition relative to citrate
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Serratia marcescens IMP-1 expressed in Escherichia coli BL21 (DE3) at 5 mM using cephalothin as substrate preincubated for 5 mins followed by substrate addition relative to control
Inhibition of Serratia marcescens IMP-1 expressed in Escherichia coli BL21 (DE3) at 5 mM using cephalothin as substrate preincubated for 5 mins followed by substrate addition
Enzyme Activity: Determination of IC50 from US Patent US10544130: "Metallo-beta-lactamase inhibitors"
Assay data:489 Active, 328 Activity ≤ 1 nM, 489 Activity ≤ 1 µM, 489 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Activity from US Patent US10227331: "Metallo-beta-lactamase inhibitors"
Assay data:369 Active, 307 Activity ≤ 1 nM, 369 Activity ≤ 1 µM, 369 Tested
BIOLOGICAL ASSAYS from US Patent US10221163: "Metallo-beta-lactamase inhibitors"
Assay data:492 Active, 462 Activity ≤ 1 nM, 492 Activity ≤ 1 µM, 492 Tested
Class B Enzyme Assay from US Patent US9708336: "Metallo-beta-lactamase inhibitors"
Assay data:825 Active, 169 Activity ≤ 1 nM, 823 Activity ≤ 1 µM, 825 Tested
Inhibition of beta-lactamase in Pseudomonas aeruginosa ATCC 27853 assessed as potentiation of amoxicillin induced antibacterial activity by measuring amoxicillin MIC after 24 hrs by agar well diffusion method (Rvb = 1 ug/ml)
Assay data:2 Tested
Inhibition of beta-lactamase in Pseudomonas aeruginosa ATCC 27853 assessed as potentiation of amoxicillin induced antibacterial activity at 10 to 100% amoxicillin to compound dilution after 24 hrs by agar well diffusion method
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Serratia marcescens IMP1 expressed in Escherichia coli BL21(DE3) using chromacef as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by HTS assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Serratia marcescens IMP1 expressed in Escherichia coli BL21(DE3) at 50 uM using chromacef as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by HTS assay relative to control
Assay data:6 Tested
Inhibition of Klebsiella pneumoniae IMP4 assessed as potentiation of meropenem-induced antibacterial activity by measuring meropenem MIC at 64 ug/ml after 16 to 18 hrs by broth microdilution method (Rvb = 20 to 40 ug/ml)
Assay data:9 Tested
Inhibition of Pseudomonas aeruginosa IMP1 metallo-beta-lactamase
Assay data:29 Active, 15 Activity ≤ 1 µM, 49 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate after 12 hrs by UV-spectrophotometric analysis
Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis
Assay data:2 Active, 18 Tested
Uncompetitive inhibition of Pseudomonas aeruginosa beta-lactamase IMP-1 assessed as formation of 4-nitrothiophenolate at pH 7 using CENTA as chromogenic substrate
Competitive inhibition of Pseudomonas aeruginosa beta-lactamase IMP-1 assessed as formation of 4-nitrothiophenolate at pH 7 using CENTA as chromogenic substrate
Assay data:8 Tested
Inhibition of Pseudomonas aeruginosa beta-lactamase IMP-1 expressed in Escherichia coli BL21(DE3) at 10 uM using CENTA as chromogenic substrate
Assay data:25 Tested
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