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Displacement of [3H]-GNF-1331 from human PORCN after 3 hrs by scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by luminescence assay
Assay data:20 Active, 12 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 22 Tested
Inhibition of mouse PORCN expressed in human HT1080 cells coexpressing Wnt/beta-catenin assessed as decrease in beta-catenin-mediated transcriptional activity at 1 to 1000 nM after 24 hrs in presence of Wnt3a by luciferase reporter gene assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of porcupine (unknown origin) expressed in HEK293 cells at 100 uM after day 1 post treatment by Super-top flash reporter gene assay relative to control
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assay
Assay data:19 Active, 3 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
Inhibition of porcupine (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of mouse PORCN expressed in human HT1080 cells coexpressing Wnt/beta-catenin assessed as decrease in beta-catenin-mediated transcriptional activity at 0.2 to 625 nM after 24 hrs in presence of Wnt3a by luciferase reporter gene assay
Inhibition of PORCN-mediated V5-tagged Wnt3A palmitoylation in human HeLa cells at 100 nM measured after over night incubation by Western blot analysis
Assay data:3 Active, 3 Tested
Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-catenin-mediated transcriptional activity after 24 hrs by Steady-Glo luciferase assay
Assay data:13 Active, 2 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 16 Tested
Inhibition of porcupine-mediated Wnt/beta-catenin signaling in human PA1 cells assessed as downregulation of LRP6 phosphorylation after 48 hrs by Western blot analysis
Assay data:2 Active, 3 Tested
Inhibition of porcupine-mediated Wnt/beta-catenin signaling in human PA1 cells assessed as downregulation of disheveled 2 phosphorylation after 48 hrs by Western blot analysis
Inhibition of porcupine-mediated Wnt/beta-catenin signaling in human PA1 cells assessed as downregulation of Axin2 mRNA expression after 24 hrs by real-time PCR analysis
Inhibition of porcupine in HEK293 cells transfected with pLibin-WNT3A plasmid assessed as downregulation of LRP6 phosphorylation at 100 nM after 48 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
Inhibition of porcupine in HEK293 cells transfected with pLibin-WNT3A plasmid assessed as downregulation of disheveled 2 phosphorylation at 100 nM after 48 hrs by Western blot analysis
Inhibition of porcupine in HEK293T cells transfected with pLibin-WNT3A plasmid assessed as reduction in Wnt3A secretion into cell culture medium at 100 nM after 48 hrs by Western blot method
Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells assessed as suppression of Wnt signaling after 48 hrs by Super-top flash reporter gene assay
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling at 5 uM after 22 hrs by Super-top flash reporter gene assay relative to control
Assay data:3 Tested
Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs by Super-top flash reporter gene assay
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells at 1 uM after 24 hrs by springerImage-Topflash reporter assay
Assay data:1 Tested
Inhibition of porcupine-mediated phosphorylation of LRP6 in human HeLa cells at 1 uM after 24 hrs by Western blot analysis
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