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Inhibition of CrtN in Staphylococcus aureus Newman after 12 resistant development passages under 0.15% v/v H2O2 assessed as reduction in appearance of non-pigmented colonies on TSA plates at 10 nM/ml
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CrtN in Staphylococcus aureus Newman after 12 resistant development passages under 0.15% v/v H2O2 assessed as reduction in appearance of non-pigmented colonies on TSA plates at 7.5 nM/ml
Inhibition of CrtN in Staphylococcus aureus Newman after 12 resistant development passages under 0.15% v/v H2O2 assessed as reduction in staphyloxanthin levels under IC90 level after 48 hrs by spectrophotometric method-based pigment inhibition assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus Mu50 assessed as increase in H2O2-induced bacterial death by measuring survival rate at preincubated for 24 hrs followed by H2O2 addition measured after 30 mins by serial dilution method (Rvb = 29.0%)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus Mu50 assessed as increase in H2O2-induced bacterial death by measuring survival rate at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 30 mins by serial dilution method (Rvb = 29.0%)
Assay data:1 Active, 2 Tested
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus LAC USA300 assessed as increase in H2O2-induced bacterial death by measuring survival rate preincubated for 24 hrs followed by H2O2 addition measured after 30 mins by serial dilution method (Rvb = 29.0%)
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus LAC USA300 assessed as increase in H2O2-induced bacterial death by measuring survival rate at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 30 mins by serial dilution method (Rvb = 29.0%)
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus USA400 MW2 assessed as increase in H2O2-induced bacterial death by measuring survival rate preincubated for 24 hrs followed by H2O2 addition measured after 30 mins by serial dilution method (Rvb = 28.7%)
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus USA400 MW2 assessed as increase in H2O2-induced bacterial death by measuring survival rate at 1 uM preincubated for 24 hrs followed by H2O2 addition measured after 30 mins by serial dilution method (Rvb = 28.7%)
Inhibition of CrtN in compound pre-treated methicillin-resistant Staphylococcus aureus Mu50 infected in human whole blood assessed as increase in whole blood-induced bacterial death by measuring survival rate at 1 uM after 6 hrs by serial dilution method (Rvb = 9.6%)
Inhibition of CrtN in compound pre-treated methicillin-resistant Staphylococcus aureus LAC USA300 infected in human whole blood assessed as increase in whole blood-induced bacterial death by measuring survival rate at 1 uM after 6 hrs by serial dilution method (Rvb = 12.3%)
Inhibition of CrtN in compound pre-treated methicillin-resistant Staphylococcus aureus USA400 MW2 infected in human whole blood assessed as increase in whole blood-induced bacterial death by measuring survival rate at 1 uM after 6 hrs by serial dilution method (Rvb = 20%)
Inhibition of Staphylococcus aureus Newman 6His-tagged CrtN expressed in Escherichia coli BL21 (DE3)/pET28a::CrtN assessed as reduction in staphyloxanthin levels using diapophytoene as substrate after overnight incubation by spectrophotometric analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus Mu50 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus LAC USA300 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
Inhibition of CrtN in methicillin-resistant Staphylococcus aureus USA400 MW2 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
Inhibition of CrtN in Staphylococcus aureus Newman assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric method-based pigment inhibition assay
Assay data:42 Active, 100 Activity ≤ 1 µM, 100 Tested
Inhibition of CrtN in Staphylococcus aureus Newman assessed as bacterial death by measuring survival rate measured at 2 hrs interval for 6 hrs by serial dilution method
Assay data:2 Active, 2 Tested
Inhibition of CrtN in Staphylococcus aureus Mu50 assessed as bacterial death by measuring survival rate measured after 6 hrs by serial dilution method (Rvb = 9.33%)
Assay data:2 Tested
Inhibition of CrtN in Staphylococcus aureus Newman assessed as bacterial death by measuring survival rate measured after 6 hrs by serial dilution method (Rvb = 8.67%)
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