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Nitric Oxide Synthase, Neuronal (nNOS) Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Activation of eNOS activity in cisplatin-treated HUVEC cells assessed as increase in intracellular cGMP level at 30 uM preincubated with eNOS inhibitor, N(G)-nitro-L-arginine methyl ester followed by compound addition and further incubated for 15 mins by radioimmunoassay
SummaryPubMed CitationRelated BioAssays by Target
Activation of eNOS activity in cisplatin-treated HUVEC cells assessed as increase in intracellular cGMP level incubated for 15 mins by radioimmunoassay
Activation of eNOS activity in cisplatin-treated HUVEC cells assessed as increase in eNOS phosphorylation at Ser1177 residue at 30 uM preincubated with PI3K inhibitor, wortmannin followed by compound addition measured after 5 to 240 mins by Western blot analysis
Activation of eNOS activity in cisplatin-treated HUVEC cells assessed as increase in eNOS phosphorylation at Ser1177 residue at 30 uM preincubated with eNOS inhibitor, N(G)-nitro-L-arginine methyl ester followed by compound addition measured after 5 to 240 mins by Western blot analysis
Activation of eNOS activity in cisplatin-treated HUVEC cells assessed as increase in eNOS phosphorylation at Ser1177 residue at 30 uM measured after 5 to 60 mins by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human eNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assay
Assay data:6 Active, 11 Tested
Inhibition of human nNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assay
Assay data:11 Active, 9 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of rat nNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
Inhibition of human eNOS assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 1 hr
Assay data:2 Active, 22 Tested
Inhibition of human nNOS assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 1 hr
Assay data:3 Active, 22 Tested
Inhibition of NOS (unknown origin)
Enzyme Inhibition Assay from US Patent US10759791: "Mammalian and bacterial nitric oxide synthase inhibitors"
Assay data:24 Active, 21 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Polarization Assay from Article 10.1074/jbc.M113.528695: "Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition Assay from US Patent US9242957: "Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors"
Assay data:24 Active, 23 Activity ≤ 1 µM, 24 Tested
Inhibition Assay from US Patent US9212144: "2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition"
Assay data:13 Active, 12 Activity ≤ 1 µM, 16 Tested
Hemoglobin Capture Assay from Article 10.1021/acs.biochem.6b00261: "Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase."
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Enzyme Inhibition Assay from US Patent US9090589: "Specific nNOS inhibitors for the therapy and prevention of human melanoma"
Assay data:8 Active, 8 Activity ≤ 1 µM, 9 Tested
In Vitro Enzyme Assay from US Patent US8927730: "Intramolecular hydrogen-bonded nitric oxide synthase inhibitors"
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
Spectral Binding Assay from Article 10.1021/bi500561h: "The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
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