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Binding affinity to Escherichia coli AmpC assessed as inhibition constant using nitrocefin as substrate by microplate reader analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to Escherichia coli TEM1 assessed as inhibition constant using nitrocefin as substrate by microplate reader analysis
Inhibition of Enterobacter cloacae AmpC
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Escherichia coli beta-lactamase TEM-1
Inhibition of Beta-Lactamase Enzymes from US Patent US10800778: "Beta-lactamase inhibitor compounds"
Assay data:39 Active, 1 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Test for beta-lactamase Inhibitory Activity from US Patent US10544146: "Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Cell Free Inhibition Assay from US Patent US9120808: "Substituted clavulanic acid"
Assay data:38 Active, 3 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 42 Tested
Inhibition Assay from US Patent US9035062: "Process for preparing a compound useful for producing an optically active diazabicyclooctane compound"
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Steady-State Kinetics Assay from Article 10.1021/bi501197t: "Detecting a quasi-stable imine species on the reaction pathway of SHV-1 -lactamase and 6 -(hydroxymethyl)penicillanic acid sulfone."
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition Assay from Article 10.1016/S1074-5521(01)00034-5: "Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase."
Assay data:33 Active, 17 Activity ≤ 1 µM, 41 Tested
Enzyme Inhibition Assay from Article 10.1016/S1074-5521(00)00052-1: "Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases."
Assay data:11 Active, 10 Activity ≤ 1 µM, 14 Tested
Beta-lactamase AmpC Inhibition Assay from Article 10.1038/nchembio.155: "Molecular docking and ligand specificity in fragment-based inhibitor discovery."
Assay data:8 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of bacterial Beta-lactamase TEM-1 (24 - 286) (unknown origin) expressed in Escherichia coli Transetta (DE3)
Assay data:10 Active, 2 Activity ≤ 1 µM, 22 Tested
Binding affinity to Enterobacter cloacae P99 beta-lactamase assessed as increase in molecular weight of enzyme-compound complex by mass-spectra analysis (Rvb = 39192 Da)
Assay data:5 Tested
Irreversible inhibition of Enterobacter cloacae P99 beta-lactamase using cephalothin as substrate by spectrophotometric analysis
Assay data:7 Tested
Irreversible inhibition of Enterobacter cloacae P99 beta-lactamase assessed as ratio of K2/K3 using cephalothin as substrate by spectrophotometric analysis
Irreversible inhibition of Enterobacter cloacae P99 beta-lactamase assessed as second-order rate constant for enzyme-inhibitor complex using cephalothin as substrate by spectrophotometric analysis
Inhibition of bacterial wild type Beta-lactamase TEM-1 pre-incubated for 5 mins before addition of chromogenic beta-lactamase substrate CENTA by spectrophotometry
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to bacterial wild type Beta-lactamase TEM-1 assessed as change in melting temperature at 100-fold molar excess compound concentration relative to apo-enzymes by SYPRO Orange dye based differential scanning fluorimetry
Inhibition of Escherichia coli TEM-1 beta-lactamase
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