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Inhibition of Gelatinase E Assay from US Patent US20230357139: "SMALL MOLECULE INHIBITORS OF BACTERIAL TOXINS"
Assay data:1 Active, 1 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Reversible inhibition of Clostridium histolyticum peptidase domain of ColH at 1.25 uM using quenched fluorescent FSI-1 as substrate incubated for 2 min by rapid dilution assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Clostridium histolyticum peptidase unit of CoLH at 100 uM relative to contol
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Clostridium histolyticum peptidase unit of CoLH at 100 uM relative to control
Assay data:2 Tested
Inhibition of Clostridium histolyticum collagenase unit of CoLH at 100 uM relative to control
Inhibition of Clostridium histolyticum CoLH at 100 uM relative to control
Assay data:1 Tested
Inhibition of Clostridium histolyticum CoLH
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Clostridium histolyticum CoLH assessed as inhibition constant using M MOCAcPro-Leu-Gly-Leu-A2pr-(DNP)Ala-Arg-NH2 as substrate incubated for 10 mins by fluorescence spectrophotometer analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Clostridium histolyticum CoLH using M MOCAcPro-Leu-Gly-Leu-A2pr-(DNP)Ala-Arg-NH2 as substrate incubated for 10 mins by fluorescence spectrophotometer analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Clostridium histolyticum peptidase unit of ColH assessed as inhibition constant incubated for 144 seconds by FRET based assay
Assay data:1 Active, 2 Tested
Inhibition of Clostridium histolyticum ColH peptidase domain expressed in Escherichia coli BL21(DE3) cells at 100 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control
Inhibition of Clostridium histolyticum ColH peptidase domain expressed in Escherichia coli BL21(DE3) cells at 1 uM using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay relative to control
Inhibition of Clostridium histolyticum ColH peptidase domain expressed in Escherichia coli BL21(DE3) cells using Mca-Ala-Gly-Pro-Pro-Gly-Pro-Dpa-Gly-Arg-NH2 as substrate preincubated for 1 hr followed by substrate addition measured for 2 mins by FRET assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
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