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Binding affinity to human NTSR2 transfected in HEK293 cells assessed as inhibition constant incubated for 60 mins in the presence of [Leu3H]NT(8-13) by radioligand competition binding assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 7 Tested
SummaryRelated BioAssays by Target
Inhibition of human NTR2
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]NT(8-13) from human NTSR2 expressed in HEK293 cell membranes by radioligand displacement assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
PRESTO-Tango GPCRome screening (NTSR2)
Assay data:1 Tested
Neurotensin receptor (h) CEREP ligand profiling
Binding affinity to NTS2 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested
Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis
Assay data:26 Active, 21 Activity ≤ 1 µM, 31 Tested
Displacement of [125I]-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter method
Assay data:18 Active, 11 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
Positive allosteric modulation of recombinant human NTR2 expressed in HEK293 cells assessed as increase in [125I]-neurotensin binding measured after 3 hrs
SummaryPubMed CitationRelated BioAssays by Target
Allosteric modulation of NTR2 (unknown origin) assessed as induction of NT (8 to 13) peptide-mediated beta-arrestin recruitment at >80 uM by pathhunter assay
Assay data:42 Tested
Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation counter analysis
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 9 Tested
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Displacement of 125I-[Tyr3]-NT from human NTS2 receptor expressed in human 1321N1 cell membranes after 30 mins by gamma counting analysis
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
Mouse NTS2 receptor (Neurotensin receptors)
Assay data:8 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human NTS2 receptor (Neurotensin receptors)
Assay data:7 Active, 7 Tested
Rat NTS2 receptor (Neurotensin receptors)
Assay data:6 Active, 6 Tested
Displacement of [leucine-3H]NT (8 to 13 residues) from human NTS2 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting
Assay data:15 Active, 12 Activity ≤ 1 µM, 16 Tested
Partial agonist activity at rat NTS2 receptor expressed in CHOK1 cells assessed as calcium mobilization by FLIPR assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Displacement of [3H]NT(8 to 13 residues) from human NTSR2 expressed in HEK293 cell membranes
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 9 Tested
Displacement of [125I]-Tyr3-NT from human NTS2 receptor expressed in 1321N1 cell membranes incubated for 30 mins by gamma-counting based competitive radioligand binding assay
Assay data:7 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested
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