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Affinity Biochemical interaction: (Biochemical assay (LPA measurement)) EUB0001066a ENPP2
Assay data:1 Active, 1 Tested
SummaryRelated BioAssays by Target
Affinity Biochemical interaction: (Biochemical assay (LPA measurement)) EUB0000318b ENPP2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity On-target Cellular interaction: (Inhibition of Autotaxin, whole blood assay) EUB0000318b ENPP2
Inhibition of ENPP2 in IL-3 and CpG-A-activated human plasmacytoid dendritic cells at 10 to 30 uM assessed as decrease in pDC activation
Inhibition of human ATX assessed as decrease in LPC hydrolysis upto 2.5 uM by Amplex Red assay
Assay data:2 Active, 2 Tested
Inhibition of human ATX assessed as decrease in LPC hydrolysis by Amplex Red assay
Inhibition of human ATX by Amplex Red assay
Inhibition of human ATX at 100 uM by Amplex Red assay relative to control
Assay data:2 Tested
Inhibition of ATX (unknown origin) incubated for 30 mins by fluorescence based analysis relative to control
Assay data:6 Tested
Inhibition of ATX (unknown origin) incubated for 30 mins by fluorescence based analysis
Assay data:4 Active, 1 Activity ≤ 1 µM, 7 Tested
Mixed type inhibition of human ATX assessed as km using LPC as substrate by Lineweaver-Burk plot analysis
Assay data:1 Active, 2 Tested
Mixed type inhibition of human ATX assessed as inhibition constant using LPC as substrate by Lineweaver-Burk plot analysis
Inhibition of mouse ATX using LPC as substrate preincubated with compound for 15 mins followed by substrate addition measured after 30 mins by Amplex Red reagent based fluorescence analysis
Assay data:4 Active, 19 Tested
Inhibition of human ATX using LPC as substrate preincubated with compound for 15 mins followed by substrate addition measured after 30 mins by Amplex Red reagent based fluorescence analysis
Assay data:8 Active, 2 Activity ≤ 1 µM, 33 Tested
Inhibition of human NPP2 expressed in COS-7 cells using pNP-TMP as substrate preincubated for 10 mins followed by substrate addition and measured after 35 mins by microplate reader analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of ATX (unknown origin) using FS-3 as substrate
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human ATX using LPC as substrate assessed as choline release measured after 1.5 hrs by fluorescence based assay
Inhibition of ATX in mouse plasma
Inhibition of ATX in human blood
Inhibition of ATX (unknown origin) using lysoPLD as substrate
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