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Selectivity interaction (CEREP panel (binding assay, receptors and ion channels)) EUB0001623a ADORA1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Eurofins CEREP Diversity Profile (receptors and ion channels)) EUB0000279b ADORA1
Selectivity interaction (SafetyScreen enzymatic and binding assays (Eurofins, panel of GPCRs, transporters, ion channels, nuclear receptors, and other enzymes)) EUB0000050b ADORA1
Selectivity interaction (Adenosine 1 receptor binding assay, human recombinant) EUB0000877a ADORA1
Inhibition of Adenosine A1 at 10.0 M in the Eurofins Panlabs Safety Screen
Activity against A1/R in the Eurofins Panlabs screen (BI) by Radioactive Assay
Activity against A1/H in the Eurofins SafetyScreen44 (BI) by Radioactive Assay (Cerep_2)
Agonist activity at human A1 adenosine receptor expressed in CHO cells
Assay data:1 Active, 1 Tested
Selectivity ratio of displacement of [3H]2-chloro-N6-cyclopentyladenosine from human A1 adenosine receptor expressed in CHO membrane in presence of PAM to displacement of [3H]2-chloro-N6-cyclopentyladenosine from human A1 adenosine receptor expressed in CHO membrane
Assay data:25 Tested
Displacement of [3H]8-cyclopentyl-1,3-dipropylxanthine from human A1 adenosine receptor expressed in CHO membrane assessed per mg protein at 10 uM incubated for 90 mins
Displacement of [3H]2-chloro-N6-cyclopentyladenosine from human A1 adenosine receptor expressed in CHO membrane assessed per mg protein at 10 uM incubated for 90 mins in presence of PAM
Displacement of [3H]2-chloro-N6-cyclopentyladenosine from human A1 adenosine receptor expressed in CHO membrane assessed per mg protein at 10 uM incubated for 90 mins
Antagonist activity at adenosine A1 receptor (unknown origin) assessed as inhibition of NECA-induced cAMP accumulation pretreated for 30 mins followed by NECA induction by GloSensor assay
Assay data:2 Tested
Binding affinity to human A1AR assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Displacement of R-PIA from human A1AR expressed in CHO cell membrane at 10 uM incubated for 60 mins by liquid scintillation counter analysis relative to control
Assay data:11 Tested
Displacement of R-PIA from human A1AR expressed in CHO cell membrane assessed as inhibition constant incubated for 60 mins by liquid scintillation counter analysis
Assay data:11 Active, 3 Activity ≤ 1 µM, 11 Tested
Displacement of [3H]DPCPX from human A1AR expressed in CHO cells membrane at 1 uM incubated for 30 mins by microplate scintillation counter method
Assay data:3 Tested
Binding affinity to adenosine receptor A1 (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human recombinant A1 receptor at 10 uM relative to control
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