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Inhibition of Purinergic P2Y, non-selective at 10.0 M in the Eurofins Panlabs Safety Screen
Assay data:1 Tested
SummaryRelated BioAssays by Target
Activity against P2Y/RA in the Eurofins SafetyScreen44 (BI) by Radioactive Assay (Old_Cerep_30)
Antagonist activity at human P2Y1R expressed in HEK293 cells assessed as inhibition of ADP-induced IP3 production preincubated for 0.5 hrs followed by ADP stimulation by ELISA analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [3H]UR-MK299 from human Y1 receptor expressed in human SK-N-MC cells measured after 90 mins by MicroBeta plate counter based competition binding assay
Assay data:2 Active, 3 Activity ≤ 1 µM, 5 Tested
Purinergic P2Y Eurofins Panlabs panel
Inhibition of human P2Y1 by FLIPR assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human P2Y1 assessed as inhibition constant
Assay data:7 Active, 7 Activity ≤ 1 µM, 9 Tested
Displacement of [beta-33p]-2-MeS-ADP from human P2Y1
Assay data:13 Active, 12 Activity ≤ 1 µM, 18 Tested
Agonist activity at human P2Y1
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human P2Y1
Antagonist activity at human P2Y1 by FLIPR assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at human P2Y1R in human 1321N1 cells assessed as efficacy relative to control
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human P2Y1R in human 1321N1 cells
Assay data:5 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 6 Tested
Antagonist activity at Meleagris P2Y1R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization at 100 uM by FLIPR assay relative to control
Assay data:5 Tested
Antagonist activity at human P2Y1 receptor assessed as inhibition constant
Antagonist activity at P2Y1R (unknown origin) expressed in human 1321N1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 15 mins in presence of IBMX by chromatography
Antagonist activity at human P2Y1R expressed in HEK293 cells assessed as inhibition of ADP-induced IP3 production preincubated for 0.5 hrs followed by ADP stimulation by ELISA
Antagonist activity at P2Y1 receptor (unknown origin)
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Binding affinity to P2Y1 receptor (unknown origin)
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