Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Biological Assay from US Patent US12018014: "Pyrrole-substituted indolone derivative or pharmaceutically acceptable salts thereof, and preparation method therefor and application thereof"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
VEGFR ADP GLO Assay from US Patent US20240109917: "PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS"
Assay data:23 Active, 13 Activity ≤ 1 µM, 485 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Mobility-Shift Assay from US Patent US11912663: "Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses"
Assay data:14 Active, 15 Activity ≤ 1 µM, 15 Tested
In Vitro Kinase Binding Assay from US Patent US20240058459: "DENDRIMER COMPOSITIONS AND METHODS FOR DRUG DELIVERY TO THE EYE"
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Tested
SummaryRelated BioAssays by Target
KDR Invitrogen Lab (UK) kinase screen (BI)
Compound was evaluated for inhibition of human KDR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:12 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 101 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:19 Active, 11 Activity ≤ 1 µM, 692 Tested
Inhibition of VEGFR2 (unknown origin) at 10 uM by biochemical hotspot kinase assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of VEGFR-2 (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISA
Inhibition of VEGFR-2 (unknown origin)
Assay data:9 Active, 8 Activity ≤ 1 µM, 10 Tested
Inhibition of His-tagged human recombinant VEGFR2 (789 to 1356 residues) expressed in insect cells at 200 nM by Z'-lyte assay
Inhibition of KDR (unknown origin) at 1 uM relative to control
Inhibition of KDR (unknown origin) using peptide substrate incubated for 90 mins in presence of ATP by HTRF method
Inhibition of N-terminal GST tagged recombinant human VEGFR2 (aa805 to 1356 residues) expressed in baculovirus expression system using Poly- (Glu4:Tyr)-biotin as substrate incubated for 80 mins in presence of ATP by kinase glo method
Assay data:8 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of VEGFR2 (unknown origin)
Inhibition of VEGF-induced human VEGFR2 autophosphorylation transfected in CHO cells by chemiluminescence assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of VEGF-induced human VEGFR2 autophosphorylation expressed in HUVEC cells measured after 2 hrs by chemiluminescence assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of human recombinant GST-fused VEGFR2 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:16 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on