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Inhibition of MRP1 in human NCI-H69AR cells assessed as maximum inhibition incubated for 180 mins in presence of daunorubicin by flow cytometry analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MRP1 in human NCI-H69AR cells assessed as maximum inhibition at 10 uM incubated for 180 mins in presence of daunorubicin by flow cytometry analysis relative to control
Assay data:8 Tested
Inhibition of MRP1 in human NCI-H69AR cells at 10 uM incubated for 180 mins in presence of daunorubicin by flow cytometry analysis relative to control
Assay data:34 Tested
Inhibition of MRP1 in human NCI-H69AR cells incubated for 180 mins in presence of daunorubicin by flow cytometry analysis
Assay data:34 Active, 28 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MRP1 (unknown origin) by calcein AM assay
Inhibition of human MRP1 expressed in human MDR cells measured for 2 hrs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MRP1 (unknown origin) measured for 2 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of MRP1 (unknown origin)
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Binding affinity to MRP1 in vincristine resistant human Eca-109 cells assessed as stabilization of protein at 100 uM incubated for 30 mins by thermal shift assay
Inhibition of MRP1 in dog MDCK-MRP1 cells assessed as inhibition of transport of fluorescent Calcein-AM measured by fluorescence based assay
Assay data:2 Tested
Reversal of MRP1-mediated doxorubicin resistance in human 2008/MRP1 cells assessed as relative fold by measuring doxorubicin IC50 at 1 uM after 5 days by Cell Titer-Glo luminescence assay relative to control
Inhibition of MRP1 in human 2008/MRP1 cells assessed as reversal of doxorubicin resistance by measuring doxorubicin IC50 at 1 uM after 5 days by Cell Titer-Glo luminescence assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Calcein-AM Assay from Article 10.1111/cbdd.12811: "Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness."
Assay data:4 Active, 14 Tested
Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 cells assessed as reversal of mitoxantrone resistance after 5 days by MTS/PMS assay
Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 cells assessed as reversal of doxorubicin resistance after 5 days by MTS/PMS assay
Assay data:2 Active, 13 Activity ≤ 1 µM, 14 Tested
Inhibition of NEM-GS-stimulated MRP1 ATPase activity (unknown origin) in presence of GSH
Assay data:1 Active, 4 Tested
Inhibition of ABCC1 (unknown origin) expressed in H69AR cells preincubated for 30 mins followed by calcein-AM addition measured at 60 secs time interval by fluorescence assay
Assay data:3 Active, 23 Tested
Inhibition of ABCC1 (unknown origin) expressed in H69AR cells assessed as reduction in daunorubicin accumulation after 180 mins by flow cytometry analysis
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of ABCC1 mediated etoposide resistant in human 2008 cells
Inhibition of MRP1 in human COR-L23/R cells assessed reduction in tritiated daunomycin efflux incubated for 2 hrs by radioactivity based assay
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