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Selectivity interaction (GPCR panel (PDSP screen)) EUB0001492b HTR1A
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (CEREB panel (panel of receptors, transporters, ion channels, and other enzymes)) EUB0001119a HTR1A
Selectivity interaction (Eurofins CEREP Diversity Profile (receptors and ion channels)) EUB0000279b HTR1A
Selectivity interaction (GPCR panel (PDSP screen)) EUB0001079a HTR1A
Selectivity interaction (Panel of non-epigenetic targets (kinases, GPCRs, ion channels, and transporters, Eurofins) ) EUB0000271b HTR1A
Selectivity interaction (GPCR panel (PDSP screen)) EUB0001072a HTR1A
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000276b HTR1A
Selectivity interaction (Safety Panel 44tm (Eurofins)) EUB0000162b HTR1A
Selectivity interaction (Serotonin 5HT1A Calcium flux assay, agonist and antagonist mode ) EUB0000877a HTR1A
Selectivity interaction (BET inhibitor selectivity panel (Human SPA binding assay)) EUB0000102c HTR1A
Inhibition of Serotonin (5-Hydroxytryptamine) 5-HT1A at 10.0 M in the Eurofins Panlabs Safety Screen
Activity against 5HT1A/R in the Eurofins Panlabs screen (BI) by Radioactive Assay
Activity against 5HT1/R in the Eurofins Panlabs screen (BI) by Radioactive Assay
Activity against 5HT1A/H in the Eurofins SafetyScreen44 (CEREP) (BI) by Radioactive Assay (Cerep_131)
Assay data:5 Tested
SafetyScreen: 5-HT1A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay, catalogue number: 131
Assay data:10 Tested
PDSP Primary Binding target: HTR1A - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintilation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter.
Assay data:25 Active, 175 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
PDSP Secondary Binding target: HTR1A - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
Assay data:22 Active, 14 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as maximal cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Partial agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293T coexpressing beta-arrestin-2 assessed as increase in cAMP accumulation incubated for 5 mins by beta-arrestin recruitment based BRET assay
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