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Displacement of [125I]apamin from SK3 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis
Displacement of [125I]apamin from human SK3 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Displacement of [125I]apamin from human SK2 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation counting analysis
Activation of SK3 (unknown origin) expressed in HEK293 cells coexpressing CaM/GFP in presence of Ca2+ by electrophysiological method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Activation of SK3 (unknown origin) expressed in HEK293 cells coexpressing CaM/GFP in presence of Ca2+ by electrophysiological method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp method relative to control
Positive modulation of SK3 in HEK293 cells in presence of Ca2+ by patch-clamp method relative to control
Positive modulation of SK3 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Positive modulation of SK2 (unknown origin)
Positive modulation of SK3 in HEK293 cells in presence of Ca2+ by patch-clamp method
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp method
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Potentiation of human KCa2.3 expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology
Potentiation of human KCa2.3 expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology relative to calcium
Potentiation of rat KCa2.2a expressed in HEK293 cells at 0.01 to 100 uM with -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology relative to calcium
Assay data:4 Tested
Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology
Assay data:13 Active, 2 Activity ≤ 1 µM, 37 Tested
Voltage-Clamp Assay from US Patent US9675591: "Methods for treating seizure disorders and pain"
SummaryCompounds, ActiveRelated BioAssays by Target
SK+Ca channel CEREP ligand profiling
SummaryRelated BioAssays by Target
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