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Selectivity interaction (Panel of non-epigenetic targets (kinases, GPCRs, ion channels, and transporters, Eurofins) ) EUB0000271b ACHE
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (SafetyScreen enzymatic and binding assays (Eurofins, panel of GPCRs, transporters, ion channels, nuclear receptors, and other enzymes)) EUB0000050b ACHE
Inhibition of Cholinesterase, Acetyl, ACES at 10.0 M in the Eurofins Panlabs Safety Screen
SafetyScreen: Acetylcholinesterase Human Enzymatic LeadHunter Assay, catalogue number: 363
Assay data:10 Tested
Inhibition of recombinant human AChE expressed in CHO cells using acetylthiocholine as substrate incubated for 30 mins by DTNB reagent based method
Assay data:1 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of Acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate incubated for 20 mins by Ellaman's method
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's assay
Inhibition of human recombinant acetylcholinesterase using acetylthiocholine as substrate by spectrophotometric analysis
Inhibition of AChE (unknown origin) by Ellman's method
Assay data:3 Tested
Inhibition of AChE (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Reactivation of paraoxon-inhibited human AChE at 10 uM incubated for 1 hr by spectrophotometry method relative to control
Reactivation of paraoxon-inhibited human AChE at 100 uM incubated for 1 hr by spectrophotometry method relative to control
Reactivation of paraoxon-inhibited human AChE at 1000 uM incubated for 1 hr by spectrophotometry method relative to control
Reactivation of paraoxon-inhibited electric eel AChE at 10 uM incubated for 1 hr relative to control
Assay data:16 Tested
Reactivation of paraoxon-inhibited electric eel AChE at 100 uM incubated for 1 hr relative to control
Reactivation of paraoxon-inhibited electric eel AChE at 1000 uM incubated for 1 hr relative to control
Inhibition of AChE (unknown origin) using ATCI as substrate preincubated for 15 min followed by substrate addition measured after 40 min by Ellman's method
Assay data:1 Active, 21 Tested
Reactivation of paraoxon-inhibited human erythrocyte AChE using acetylthiocholine as substrate assessed as fold change in second order reactivation rate constant preincubated with paraoxon for 15 mins followed by compound and substrate addition and measured every 5 to 10 mins for 120 mins by DTNB based Ellman's method relative to obidoxime
Assay data:2 Tested
Reactivation of paraoxon-inhibited human erythrocyte AChE using acetylthiocholine as substrate assessed as second order reactivation rate constant preincubated with paraoxon for 15 mins followed by compound and substrate addition and measured every 5 to 10 mins for 120 mins by DTNB based Ellman's method
Assay data:14 Tested
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