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Inhibition of human Cathepsin L using Z-Leu-Arg-AMC as substrate upto 50 uM incubated for 60 mins by FRET assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human cathepsin L upto 40 uM preincubated for 20 mins
Inhibition of human Cathepsin L using Z-VVR-AMC as substrate measured for 10 mins by fluorescence based assay
Assay data:2 Tested
Inhibition of human Cathepsin L2
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human Cathepsin L
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human Cathepsin L using fluorogenic substrate by FRET-based assay
Inhibition of human Cathepsin L using HiLyte Fluor488TM as substrate pre-incubated for 60 mins in presence of GSH followed by substrate addition measured after 30 mins by fluorescence based assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 3 Tested
Covalent irreversible inhibition of human Cathepsin L using Cbz-Phe-Arg-AMC as substrate assessed as reduction in enzyme recovery at 5 fold IC50 preincubated for 60 mins followed by dilution to 1 fold IC50 and substrate addition by fluorescence based assay
Assay data:3 Active, 3 Tested
Inhibition of human Cathepsin L using Cbz-Phe-Arg-AMC as substrate assessed as inhibition constant measured for 10 mins by fluorescence assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Prodrug activation assessed as human cysteine cathepsin L mediated gemcitabine release at 100 ug incubated for 24 hrs by HPLC analysis
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of human Cathepsin L using Cbz-Phe-Arg-AMC as substrate by fluorescence spectrophotometric analysis
Inhibition of Cathepsin L (unknown origin) using Z-VVR-AMC as fluorogenic substrate at 20 uM preincubated for 10 mins followed by substrate addition and measured for 10 mins by fluorescence based assay
Inhibition of Cathepsin L (unknown origin) using Z-VVR-AMC as fluorogenic substrate preincubated for 10 mins followed by substrate addition and measured for 10 mins by fluorescence based assay
Irreversible inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 mins by fluorescence based microplate reader analysis
Assay data:1 Active, 5 Tested
Irreversible inhibition of human cathepsin L using Z-FR-AMC as substrate assessed as second-order rate constant for enzyme inactivation, ratio of Kinact/Ki preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 mins by fluorescence based microplate reader analysis
Assay data:17 Tested
Inhibition of human cathepsin L using Z-FR-AMC as substrate preincubated for 20 mins followed by pre-activated enzyme addition and measured after 15 mins by fluorescence based microplate reader analysis
Inhibition of recombinant cathepsin L (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant human CTSL-mediated substrate cleavage
Inhibition of human cathepsin L at 100 uM
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