Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibitor of ACOASYN in the Eurofins Panlabs screen (BI) by Radioactive Assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Biochemical Activity ACSS2 Assay from US Patent US20240009175: "TETRAZOLE DERIVATIVES"
Assay data:51 Active, 7 Activity ≤ 1 nM, 50 Activity ≤ 1 µM, 51 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical Activity ACSS2 Assay from US Patent US20230271956: "AMIDE DERIVATIVES"
Assay data:100 Active, 9 Activity ≤ 1 nM, 94 Activity ≤ 1 µM, 100 Tested
Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into histones measured after 24 hrs by scintillation counting based cellular histone assay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids measured after 24 hrs by scintillation counting based cellular lipids assay
Inhibition of human recombinant ACSS2 assessed as AMP release using Coenzyme A/ATP as co-substrates by AMP Glo assay
Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into histones by microbeta scintillation counting analysis
Inhibition of ACSS2 in human HCT-15 cells assessed as inhibition of 14C acetate incorporation into fatty acids by microbeta scintillation counting analysis
Inhibition of human recombinant ACSS2 incubated for 180 mins by AMP Glo assay
Inhibition of ACSS2 in human HCT116 cells pre-incubated for 2 hrs before [1,2-14C] sodium acetate addition and measured after 3 hrs by [14C]-Acetate uptake assay
Assay data:119 Active, 120 Activity ≤ 1 µM, 120 Tested
Inhibition of N-terminal 6x-histidine tagged human ACSS2 expressed in insect cells assessed as reduction in pyrophosphate production using CoA and ATP incubated for 30 mins by pyrophosphatase coupled enzymatic assay
Assay data:306 Active, 379 Activity ≤ 1 µM, 379 Tested
Inhibition of ACSS2 in human MDA-MB-468 cells assessed as 13C-acetate incorporation incubated for 5 hrs measured under hypoxic conditions by LCMS analysis
Assay data:12 Active, 4 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
In Vivo effect for the hypolipidemic activity on Acetyl-coenzyme A synthetase in CF1 mice after 16 days of oral administration at a dose of 60 mg/kg
SummaryPubMed CitationRelated BioAssays by Target
In Vitro evaluation for the CF1 liver enzyme activity on Acetyl-coenzyme A synthetase at concentration 50 uM
In Vivo effect for the hypolipidemic activity on Acetyl-coenzyme A synthetase in CF1 mice after 16 days of oral administration at a dose of 20 mg/kg
In Vitro evaluation for the CF1 liver enzyme activity on Acetyl-coenzyme A synthetase at concentration 200 uM
In Vitro evaluation for the CF1 liver enzyme activity on Acetyl-coenzyme A synthetase at concentration 100 uM
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on