Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of human ADCY8 assessed assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human ADCY5 assessed assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
Inhibition of human ADCY2 assessed assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
Inhibition of human ADCY1 assessed assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
Inhibition of human ADCY9 assessed assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
Inhibition of forskolin stimulated human AC5 activity in C3 and AC6-knockout HEK293 cells assessed as forskolin stimulated cAMP accumulation at 10 uM incubated for 30 mins followed by forskolin stimulation in presence of IBMX for 1 hr by HTRF assay relative to control
Assay data:5 Tested
Potentiation of PMA-stimulted human AC2 activity in AC3 and AC6-knockout HEK293 cells PMA stimulated cAMP accumulation at 10 uM incubated for 30 mins followed by PMA stimulation in presence of IBMX for 1 hr by HTRF assay relative to control
Inhibition of Ca2+/ CAM stimulated human AC8 expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation at 10 uM incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay relative to control
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Ca2+/ CAM stimulated human AC8 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay relative to control
Assay data:36 Tested
Inhibition of Ca2+/ CAM stimulated human AC8 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay
Assay data:25 Active, 7 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Ca2+/ CAM stimulated human AC1 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay
Assay data:33 Active, 22 Activity ≤ 1 µM, 36 Tested
Inhibition of human AC3 expressed in HEK293 cells assessed as remaining activity by measuring cAMP level at 30 uM relative to control
Assay data:24 Tested
Inhibition of human AC2 expressed in HEK293 cells assessed as remaining activity by measuring cAMP level at 30 uM relative to control
Inhibition of human AC1 expressed in HEK293 cells assessed as remaining activity by measuring cAMP level at 30 uM relative to control
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as reduction in IL6 level by measuring IL6 level at 50 uM measured after 24 hrs by ELISA relative to control
Assay data:2 Tested
Potency index, ratio of forskolin EC50 to test compound EC50 for agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level
Agonist activity at recombinant human AC2 expressed in HEK293 cells assessed as increase in cAMP level by measuring cAMP level at 50 uM measured after 30 mins by LANCE Ultra cAMP Detection kit method relative to control
Assay data:59 Tested
Agonist activity at recombinant human AC8 expressed in HEK293 cells assessed as increase in cAMP level at 50 uM measured after 30 mins by LANCE Ultra cAMP Detection kit method
Assay data:2 Active, 3 Tested
Agonist activity at recombinant human AC5 expressed in HEK293 cells assessed as increase in cAMP level at 50 uM measured after 30 mins by LANCE Ultra cAMP Detection kit method
Agonist activity at recombinant human AC1 expressed in HEK293 cells assessed as increase in cAMP level at 50 uM measured after 30 mins by LANCE Ultra cAMP Detection kit method
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on