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Inhibition of human PP2AC using [3H]-phosphohistone as substrate
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PP2A (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PP2A alpha (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP assay
Inhibition of PP2Ca (unknown origin) assessed as change in enzyme activity at 150 uM incubated for 15 mins relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to PPP2CB in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human PP2A catalytic subunit L309 deletion mutant using DIFMUP as substrate pretreated for 10 mins followed by substrate addition measured every 15 secs for 30 mins by fluorescence assay
Inhibition of recombinant PP2A (unknown origin) by standard phosphorylase-a inhibition assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of purified human red blood cell protein phosphatase 2A using DiFMUP substrate incubated for 30 mins
Assay data:5 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of recombinant PP2A1 (unknown origin) pre-incubated for 15 mins with enzyme before 32P-labeled MBP substrate addition
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Late stage assay provider results from the probe development effort to identify inhibitors of protein phosphatase methylesterase 1 (PME-1): Inhibition of PME-1-mediated demethylation of PP2A
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Displacement of [125]MC-YR from rabbit skeletal muscle protein phosphatase 2A after 1 hr
SummaryPubMed CitationRelated BioAssays by Target
The compound was tested for the selectivity against protein phosphatases 2A; Not determined
The compound was tested for the selectivity against protein phosphatases 2A; ND means not determined
The compound was tested for the selectivity against protein phosphatases 2A
Assay data:6 Tested
Selectivity against protein phosphatase 2A
Assay data:28 Tested
Inhibitory concentration against protein phosphatase 2A (PP2A) using phosphorylase-a assay
Assay data:4 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested
Inhibitory concentration against protein phosphatase 2A (PP2A) using pNPP assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 17 Tested
Inhibitory concentration against Protein phosphatase 2A (25 nM) isolated from bovine myocardial tissue
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Experimentally measured binding affinity data derived from PDB
Assay data:3073 Active, 3073 Tested
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