Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19637151.

RFMS Human PAD4 Functional Assay from US Patent US11981680: "Substituted thienopyrroles as PAD4 inhibitors"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 1

Assay data:48 Active, 48 Activity ≤ 1 µM, 48 Tested

AID:: 1963715

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19202002.

In Vitro PAD4 BAEE Biochemical Assay from US Patent US11878965: "Inhibitors of peptidylarginine deiminases"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 1

Assay data:299 Active, 268 Activity ≤ 1 µM, 320 Tested

AID:: 1920200

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19200463.

FP Binding Assay from US Patent US11833156: "Heterocyclic compounds as pad inhibitors"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 1

Assay data:23 Active, 22 Activity ≤ 1 µM, 23 Tested

AID:: 1920046

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19190954.

Rapid-Fire Mass Spectrum (RFMS) Assay from US Patent US11524959: "Indole and azaindole inhibitors of pad enzymes"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 1

Assay data:1076 Active, 1053 Activity ≤ 1 µM, 1076 Tested

AID:: 1919095

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18755315.

Inhibition of human His-Sumo-tagged PAD4 (A2 to P663 residues) expressed in Escherichia coli BL21 (DE3) cells using BAEE as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by fluorescence assay

Source:: ChEMBL

Protein Target:: Protein-arginine deiminase type-4

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 1875531

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18138066.

Inhibition of human PAD4 using BAEE as substrate incubated for 30 mins by spectrophotometric based assay

Source:: ChEMBL

Protein Target:: Protein-arginine deiminase type-4

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 1813806

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18130827.

Inhibition of PAD4 (unknown origin)

Source:: ChEMBL

Protein Target:: Protein-arginine deiminase type-4

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1813082

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18067658.

FP Binding Assay from US Patent US11426412: "Imidazo-pyridine compounds as PAD inhibitors"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 1

Assay data:26 Active, 9 Activity ≤ 1 µM, 29 Tested

AID:: 1806765

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 18067649.

Biochemical Assay from US Patent US11426412: "Imidazo-pyridine compounds as PAD inhibitors"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 1

Assay data:76 Active, 54 Activity ≤ 1 µM, 84 Tested

AID:: 1806764

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180618310.

Biological Assay (AR) from US Patent US11198681: "Heteroaryl inhibitors of PAD4"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 1

Assay data:41 Active, 24 Activity ≤ 1 µM, 56 Tested

AID:: 1806183

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180618211.

Biological Assay (RFMS) from US Patent US11198681: "Heteroaryl inhibitors of PAD4"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 2

Assay data:43 Active, 11 Activity ≤ 1 µM, 80 Tested

AID:: 1806182

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180562012.

Inhibition Assay from US Patent US11026937: "Heteroaryl inhibitors of PAD4"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 1

Assay data:15 Active, 134 Tested

AID:: 1805620

Summary Compounds, Active Related BioAssays by Target

Select item 180462713.

Inhibition Assay from US Patent US10716791: "Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-1; ...
Total:: 3

Assay data:17 Tested

AID:: 1804627

Summary Related BioAssays by Target

Select item 180454614.

RapidFire Mass Spectrometry (RFMS) Activity Assay from US Patent US10703741: "Covalent inhibitors of PAD4"

Source:: BindingDB

Protein Targets:: Protein-arginine deiminase type-4; ...
Total:: 2

Assay data:7 Active, 5 Activity ≤ 1 µM, 16 Tested

AID:: 1804546

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 165150215.

Inhibition of PAD4 (unknown origin) in presence of 2 mM Ca

Source:: ChEMBL

Protein Target:: Protein-arginine deiminase type-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1651502

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165150116.

Inhibition of PAD4 (unknown origin)

Source:: ChEMBL

Protein Target:: Protein-arginine deiminase type-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1651501

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 163299817.

Inhibition of recombinant human GST-tagged PAD4 expressed in Escherichia coli BL21-DE3 pLysS assessed as reduction in reduction in residual activity preincubated for 15 mins followed by addition of N-benzoylated arginine ethyl ester hydrochloride measured after 15 mins by colder assay

Source:: ChEMBL

Protein Target:: Protein-arginine deiminase type-4

Assay data:1 Active, 8 Tested

AID:: 1632998

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 162540518.

Displacement of GSK215 from full length PAD4 (unknown origin) after 50 mins by fluorescence polarization assay in absence of calcium

Source:: ChEMBL

Protein Target:: Protein-arginine deiminase type-4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1625405

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 151193819.

Inhibition of recombinant human PAD4 at 200 uM using N-alpha-benzoyl-L-arginine ethyl ester as substrate by fluorescence based analysis

Source:: ChEMBL

Protein Target:: Protein-arginine deiminase type-4

Assay data:1 Tested

AID:: 1511938

Summary PubMed Citation Related BioAssays by Target

Select item 147448620.

Inhibition of full length recombinant human N-terminal GST-tagged PAD4 expressed in baculovirus infected Sf9 cells up to 10 mM using benzoyl arginine ethylester as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by colorimetric assay

Source:: ChEMBL

Protein Target:: Protein-arginine deiminase type-4

Assay data:9 Tested

AID:: 1474486

Summary PubMed Citation Related BioAssays by Target

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Proteins (28)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (56)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (2)
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Activity (IC50, etc) ≤ 1 µM (25)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
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Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (3)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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BioAssays extracted from the literature
NIH MLP (25)
BioAssays deposited by the NIH Molecular Libraries Program

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