Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19583601.

Inhibition of CLK2 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:3 Tested

AID:: 1958360

Summary PubMed Citation Related BioAssays by Target

Select item 19476792.

Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:46 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 56 Tested

AID:: 1947679

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19340033.

Inhibition of human CLK2 measured by DSF assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Tested

AID:: 1934003

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19340004.

Inhibition of CLK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1934000

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19339865.

Inhibition of human CLK2 administered orally

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1933986

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19339806.

Inhibition of human CLK2 by NanoBRET assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1933980

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19339777.

Inhibition of human CLK2

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:28 Active, 1 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 28 Tested

AID:: 1933977

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19339768.

Inhibition of human CLK2 mediated phosphorylation of SRSF4 in hMSCs assessed by TCF/LEF reporter assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Tested

AID:: 1933976

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19339759.

Inhibition of human CLK2 mediated phosphorylation of SRSF5 in hMSCs assessed by TCF/LEF reporter assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Tested

AID:: 1933975

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 193397410.

Inhibition of human CLK2 mediated phosphorylation of SRSF6 in hMSCs assessed by TCF/LEF reporter assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Tested

AID:: 1933974

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 193397311.

Inhibition of Human CLK2 mediated phosphorylation of SRSF4 in human chondrocytes assessed by TCF/LEF reporter assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Tested

AID:: 1933973

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 193397212.

Inhibition of Human CLK2 mediated phosphorylation of SRSF5 in human chondrocytes assessed by TCF/LEF reporter assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Tested

AID:: 1933972

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 193397113.

Inhibition of Human CLK2 mediated phosphorylation of SRSF6 in human chondrocytes assessed by TCF/LEF reporter assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Tested

AID:: 1933971

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 193396914.

Inhibition of human CLK2 at 1 uM

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:2 Tested

AID:: 1933969

Summary PubMed Citation Related BioAssays by Target

Select item 193258515.

Inhibition of CLK1/2/4 (unknown origin) relative to control

Source:: ChEMBL

Protein Targets:: Dual specificity protein kinase CLK1; ...
Total:: 3

Assay data:1 Tested

AID:: 1932585

Summary PubMed Citation Related BioAssays by Target

Select item 193226516.

Inhibition of CLK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1932265

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192016217.

Biochemical Assay for Inhibitors of CLK2 Kinase Activity Assay from US Patent US11866436: "Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof"

Source:: BindingDB

Protein Targets:: Dual specificity protein kinase CLK2; ...
Total:: 1

Assay data:181 Active, 131 Activity ≤ 1 µM, 181 Tested

AID:: 1920162

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 191422218.

Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000009b CLK2

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Tested

AID:: 1914222

Summary Related BioAssays by Target

Select item 191411819.

Selectivity interaction (SelectScreen (Invitrogen)) EUB0000715a CLK2

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914118

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191407620.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000138c CLK2

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK2

Assay data:1 Tested

AID:: 1914076

Summary Related BioAssays by Target

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Target

Proteins (8)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (143)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (16)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (116)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (137)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (3)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (282)
BioAssays extracted from the literature
NIH MLP (4)
BioAssays deposited by the NIH Molecular Libraries Program
Other (49)
BioAssays deposited by other experimentalists

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