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Selectivity interaction (Fluorescence polarization ligand binding assay (2 mM calcium)) EUB0000223bCl PADI4
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (NH3 release assay (PADI4 functional assay)) EUB0000223bCl PADI4
Selectivity interaction (Enzymatic assay (citrulline production by recombinant PADI4 enzyme)) EUB0000223bCl PADI4
Assay data:1 Active, 1 Tested
Selectivity interaction (Fluorescence polarization ligand binding assay (2 mM calcium)) EUB0000266bCl PADI4
Affinity Biochemical interaction: (Fluorescence polarization binding assay (0 mM Ca)) EUB0000223bCl PADI4
Affinity Biochemical interaction: (Fluorescence polarization binding assay (0 mM Ca)) EUB0000266bCl PADI4
Assay data:1 Tested
Affinity Phenotypic Cellular interaction: (NH3 release assay (PADI4 functional assay)) EUB0000266bCl PADI4
Inhibition of N-terminal GST-tagged PAD4 (unknown origin) expressed in Escherichia coli BL21 (DE3) measured after 1 hr by colorimetric assay
Inhibition of N-terminal full length recombinant human PAD4 expressed in Escherichia coli Rosetta cells
Assay data:1 Active, 2 Tested
Inhibition of N-terminal GST-tagged PAD4 (unknown origin) expressed in Escherichia coli incubated for 1 hr by spectrophotometric method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human recombinant PAD4 using TSTGGRQGSHH peptide as substrate preincubated for 30 mins followed by substrate addition and measured after 90 mins by RapidFire mass spectroscopy analysis
Assay data:6 Activity ≤ 1 µM, 6 Tested
Inhibition of human PAD4 using BAEE as substrate preincubated with enzyme for 30 mins followed by substrate addition for 90 mins and later incubated with phenyl glyoxal for 30 mins by RFMS assay
Inhibition of PAD4 (unknown origin) in presence of 2 mM Ca
Assay data:2 Active, 2 Tested
RFMS Human PAD4 Functional Assay from US Patent US11981680: "Substituted thienopyrroles as PAD4 inhibitors"
Assay data:48 Active, 48 Activity ≤ 1 µM, 48 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro PAD4 BAEE Biochemical Assay from US Patent US11878965: "Inhibitors of peptidylarginine deiminases"
Assay data:299 Active, 268 Activity ≤ 1 µM, 320 Tested
FP Binding Assay from US Patent US11833156: "Heterocyclic compounds as pad inhibitors"
Assay data:23 Active, 22 Activity ≤ 1 µM, 23 Tested
Rapid-Fire Mass Spectrum (RFMS) Assay from US Patent US11524959: "Indole and azaindole inhibitors of pad enzymes"
Assay data:1076 Active, 1053 Activity ≤ 1 µM, 1076 Tested
Inhibition of human His-Sumo-tagged PAD4 (A2 to P663 residues) expressed in Escherichia coli BL21 (DE3) cells using BAEE as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by fluorescence assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PAD4 using BAEE as substrate incubated for 30 mins by spectrophotometric based assay
Inhibition of PAD4 (unknown origin)
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