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Enzyme Inhibition Assay from Article 10.1021/jm801224t: "Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents."
Assay data:4 Active, 4 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1021/jm7010673: "Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase."
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of Methanobacterium thermoautotrophicum ODCase
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Methanobacterium thermoautotrophicum ODCase by isothermal titration calorimetry
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Ratio of Ki for CMP to Ki for compound against Methanobacterium thermoautotrophicum ODCase by isothermal titration calorimetry
Assay data:1 Tested
Covalent binding affinity to Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase by mass spectroscopy analysis
Assay data:3 Active, 3 Tested
Inhibition of Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase by VP-ITC microcalorimeter
Irreversible inhibition of Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Competitive inhibition of Methanothermobacter thermautotrophicus uridine 5'-monophosphate synthase after overnight incubation at room temperature by Lineweaver-Burke plot analysis
Assay data:1 Active, 1 Tested
Reversible inhibition of Methanothermobacter thermautotrophicus uridine 5'-monophosphate synthase at 0.5 to 5 mM after overnight incubation at room temperature by VP-ITC microcalorimetry
Inhibition of Methanothermobacter thermautotrophicus uridine 5'-monophosphate synthase after overnight incubation at room temperature by VP-ITC microcalorimetry
Reversible inhibition of Methanobacterium thermoautotrophicum ODCase
Assay data:3 Active, 3 Activity ≤ 1 µM, 8 Tested
Inhibition of Methanobacterium thermoautotrophicum ODCase at 50 uM after 8 hrs
Inhibition of Methanobacterium thermoautotrophicum ODCase at 250 uM in less than 30 mins
Affinity for Methanobacterium thermoautotrophicum ODCase at 25 degreeC by ITC method
Affinity for Methanobacterium thermoautotrophicum ODCase at 55 degreeC by ITC method
Inhibition of Methanobacterium thermoautotrophicum ODCase at 55 degreeC by competitive binding assay
Experimentally measured binding affinity data derived from PDB
Assay data:3073 Active, 3073 Tested
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