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Selectivity interaction (GPCR panel (PDSP screen)) EUB0001079a HTR1E
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (GPCR panel (PDSP screen)) EUB0001072a HTR1E
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000276b HTR1E
Selectivity interaction (GPCR panel (PDSP screen)) EUB0001066a HTR1E
PDSP Primary Binding target: HTR1E - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintilation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter.
Assay data:12 Active, 175 Tested
PDSP Secondary Binding target: HTR1E - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintillation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter. Compounds showing a minimum of 50% inhibition at 10 uM concentration are carried forward in this secondary binding assay to determine equilibrium binding affinity.
Assay data:11 Active, 7 Activity ≤ 1 µM, 11 Tested
Binding affinity to human 5HT1E receptor assessed as inhibition constant
Displacement of [3H]5-HT from 5-HT1E receptor (unknown origin) assessed as inhibition binding at 10 uM relative to control
Binding affinity to 5-HT1E (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Tested
Inhibition of 5-HT1E (unknown origin) at 10 uM relative to control
Inhibition of 5-HT1E receptor (unknown origin) at 10 uM
SummaryPubMed CitationRelated BioAssays by Target
Radioligand Binding Assay from US Patent US11642336: "5-HT2A agonists for use in treatment of depression"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a HTR1E
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity to 5-HT1E receptor (unknown origin) at 10000 nM by radioligand displacement assay relative to control
Inhibition of serotonin 5-HT1E receptor (unknown origin) at 10 uM relative to control
Binding affinity to 5HT1E receptor (unknown origin) assessed as inhibition constant
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of 5HT1E receptor (unknown origin)
Binding affinity to 5-HT1ER (unknown origin)
Assay data:8 Active, 2 Activity ≤ 1 µM, 16 Tested
GPCRScan assay: inhibition of 5-HT1E
Assay data:2 Active, 181 Tested
PRESTO-Tango GPCRome screening (HTR1E)
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