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Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition by [14C]-counting analysis
Assay data:6 Active, 5 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MTP (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of MTP in human HepG2 cells assessed as inhibition of apoB secretion after 40 hrs by ELISA
Assay data:25 Active, 8 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA
Assay data:19 Active, 19 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
Inhibition of MTP in human HepG2 cells assessed as unbound drug level causing inhibition of apoB secretion after 40 hrs by ELISA relative to dirlotapide
Assay data:13 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of microsomal triglyceride transfer protein by cell based assay
Assay data:2 Tested
Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISA
Assay data:10 Active, 2 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 10 Tested
Inhibition of MTP assessed as inhibition of apoB secretion from human HepG2 cells
Inhibition of intestinal MTP in rat by murine gut retention assay
Assay data:4 Tested
Inhibition of MTP in canine liver microsomes
Assay data:58 Active, 72 Activity ≤ 1 µM, 81 Tested
In vitro inhibitory concentration against human Microsomal triglyceride transfer protein
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
In vitro inhibition concentration required against triglyceride transfer of human Microsomal triglyceride transfer protein
Inhibitory activity against microsomal triglyceride transfer protein (MTP)
Assay data:34 Active, 25 Activity ≤ 1 µM, 39 Tested
In vitro inhibitory activity against MTP using MTP transfer assay
Assay data:49 Active, 49 Activity ≤ 1 µM, 50 Tested
In vitro inhibition of human microsomal triglyceride transfer protein using triglyceride transfer assay
In vitro inhibition of human microsomal triglyceride transfer protein in HepG2 cells using apoB secretion assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
In vitro inhibition of human Microsomal Triglyceride Transfer Protein, (triglyceride transfer assay)
Assay data:6 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
In vitro inhibition of human Microsomal Triglyceride Transfer Protein (triglyceride transfer assay)
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