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Binding affinity to MARS in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human mitochondrial MetRS aminoacylation activity assessed as reduction in [3H]methionine incorporation into Escherichia coli tRNA pre-incubated for 15 mins before tRNA addition and measured after 120 mins by scintillation counting
Assay data:7 Active, 8 Tested
Inhibition of [35S]methionyl incorporation by Escherichia coli methionyl-tRNA synthetase (MetRS)
Assay data:3 Active, 14 Tested
Inhibitory concentration against methionyl-tRNA synthetase was determined by measuring decrease of the aminoacylation product [35S]- methionyl tRNA of Escherichia coli
Assay data:11 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibitory activity against Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)
Assay data:12 Active, 5 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human methionyl-tRNA synthetase (fMetRS) at the concentration of 10 uM
Assay data:7 Tested
Inhibitory activity against human methionyl-tRNA synthetase (hMetRS).
Assay data:26 Tested
Inhibition of human methionyl-tRNA synthetase (fMetRS)
Assay data:15 Tested
Inhibition of Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS) at the concentration of 10 uM
Assay data:6 Tested
Assay data:11 Active, 5 Activity ≤ 1 µM, 16 Tested
Inhibition of Staphylococcus aureus methionyl-tRNA synthetase (SaMetRS)
Assay data:16 Active, 14 Activity ≤ 1 µM, 16 Tested
In vitro inhibitory concentration against Staphylococcus aureus Methionyl-tRNA synthetase
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
In vitro inhibitory concentration against Methionyl-tRNA synthetase in a pyrophosphate exchange assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibitory activity against Escherichia coli Methionyl-tRNA synthetase was determined
Assay data:5 Active, 1 Activity ≤ 1 µM, 8 Tested
Inhibitory activity against Enterococci faecalis methionyl-tRNA synthetase (EfMetRS)
Assay data:6 Active, 10 Tested
Inhibition of Enterococci faecalis methionyl-tRNA synthetase (EfMetRS) at the concentration of 10 uM
Assay data:5 Tested
Inhibition of Enterococci faecalis methionyl-tRNA synthetase (EfMetRS); Inactive
Assay data:1 Tested
Inhibition of Enterococci faecalis methionyl-tRNA synthetase (EfMetRS)
Assay data:9 Active, 1 Activity ≤ 1 µM, 16 Tested
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