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Agonist activity at THRalpha LBD (unknown origin) transiently transfected in HEK293T cells at 1 uM incubated for 16 hrs by Gal4-hybrid reporter gene based Dual-glo luciferase assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Agonist activity at human THRalpha-LBD transfected in HEK293T cells co-transfected with pFR-Luc/pRL-SV40 assessed as transfection efficiency by measuring luciferase activity measured after 16 hrs by Gal4 hybrid reporter gene assay
Assay data:2 Tested
Antagonist activity at NR1A2 (unknown origin) at 1 uM
Antagonist activity at NR1A1 (unknown origin) at 1 uM
Inverse agonist activity at NR1A2 (unknown origin) at 1 uM
Inverse agonist activity at NR1A1 (unknown origin) at 1 uM
Agonist activity at NR1A2 (unknown origin) at 1 uM
Agonist activity at NR1A1 (unknown origin) at 1 uM
Modulation activity at THRalpha LBD (unknown origin) transfected in human HEK293T cells co-transfected with pFR-Luc/pRL-SV40 assessed as fold activation of luciferase activity at 30 uM incubated for 16 hrs by Gal4 hybrid reporter gene assay relative to control
Agonist activity at THRbeta (unknown origin) transfected in african green monkey COS7 cells assessed transactivation incubated at 1 uM for 16 hrs by luciferase assay
Activation of pGAL4 fused THRbeta LBD (unknown origin) transfected in HEK293 cells cotransfected with pG5-Luc and pRL-TK incubated for 24 hrs by Renilla/Firefly based dual-glo luciferase assay
Assay data:3 Tested
Agonist activity at TRbeta (unknown origin) expressed in CHO-K1 cells
Agonist activity at human GAL4-fused THRbeta LBD expressed in human HEK293T cells cotransfected with pFR-Luc and pRL-SV40 assessed as increase in luciferase activity at 30 uM incubated for 16 hrs by Dual-Glo luciferase assay relative to control
Agonist activity at human GAL4-fused THRalpha LBD expressed in human HEK293T cells cotransfected with pFR-Luc and pRL-SV40 assessed as increase in luciferase activity at 30 uM incubated for 16 hrs by Dual-Glo luciferase assay relative to control
Agonist activity at human GAL4-fused THRbeta LBD expressed in human HEK293T cells cotransfected with pFR-Luc and pRL-SV40 assessed as increase in luciferase activity at 1 uM incubated for 16 hrs by Dual-Glo luciferase assay relative to control
Agonist activity at human GAL4-fused THRalpha LBD expressed in human HEK293T cells cotransfected with pFR-Luc and pRL-SV40 assessed as increase in luciferase activity at 1 uM incubated for 16 hrs by Dual-Glo luciferase assay relative to control
THR/RXR Heterodimer Assay for Thyroid Hormone Receptor Agonist Screening from US Patent US20240059682: "THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS"
Assay data:26 Active, 25 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Thyroid Hormone Receptor Agonist Screening from US Patent US20240059682: "THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
THR Reporter Gene Method from US Patent US20240059676: "THYROID HORMONE RECEPTOR b SELECTIVE AGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF"
Assay data:32 Active, 21 Activity ≤ 1 µM, 38 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Agonist activity at human THRbeta transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase activity incubated for 16 hrs by Steady-Glo luciferase assay
Assay data:15 Active, 15 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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