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Inhibition of human GALK1 in GALT-deficient human fibroblast assessed as reduction in gal-1P level at 3 uM incubated for 2 to 4 hrs by cellular Gal-1P accumulation assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human GALK1 in GALT-deficient human fibroblast assessed as reduction in gal-1P level incubated for 2 to 4 hrs by cellular Gal-1P accumulation assay
Inhibition of recombinant human GALK1 using galactose as substrate incubated for 1 hrs in the presence of ATP by Kinase-Glo reagent based luminescence assay
Assay data:62 Active, 18 Activity ≤ 1 µM, 73 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of GALK (unknown origin) incubated for 1 hr and measured by qHTS assay realtive to control
Assay data:91 Tested
SummaryRelated BioAssays by Target
Inhibition of GALK (unknown origin) incubated for 1 hr and measured by qHTS assay
Assay data:40 Active, 3 Activity ≤ 1 µM, 91 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant human GALK1 using ATP as substrate incubated for 1 hr and measured by Kinase-Glo assay
Assay data:210 Active, 47 Activity ≤ 1 µM, 284 Tested
qHTS Assay from US Patent US9447087: "Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders"
Assay data:41 Active, 3 Activity ≤ 1 µM, 88 Tested
Inhibition of His6-tagged recombinant human GALK expressed in Escherichia coli HMS174 (DE3) at 5 to 15 uM incubated for 60 mins using galactose and ATP by Kinase-Glo reagent based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of His6-tagged recombinant human GALK expressed in Escherichia coli HMS174 (DE3) by pyruvate kinase/lactate dehydrogenase-coupled assay
Assay data:4 Active, 4 Tested
Inhibition of His6-tagged recombinant human GALK expressed in Escherichia coli HMS174 (DE3) incubated for 60 mins using galactose and ATP by Kinase-Glo reagent based assay
Assay data:34 Active, 34 Tested
qHTS Assay for Inhibitors of Human Galactokinase (GALK): NCGC Sytravon Library Screen
Assay data:1 Active, 503 Activity ≤ 1 µM, 44000 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS for Inhibitors of Human Galactokinase (GALK): Confirmation Assay for SAR round 4
Assay data:13 Active, 46 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS for Inhibitors of Human Galactokinase (GALK): SAR round 3
Assay data:23 Active, 189 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of human galactosidase at >50 uM after 30 mins by Kinase-GloTM assay
Assay data:6 Tested
Inhibition of galactosidase in human primary fibroblasts derived from GALT-deficient patients assessed as reduction in accumulation of gal-1P at 100 uM preincubated overnight prior galactose challenge measured after 4 hrs
Inhibition of galactosidase in human primary fibroblasts derived from GALT-deficient patients assessed as reduction in accumulation of gal-1P at 50 uM preincubated overnight prior galactose challenge measured after 4 hrs
Assay data:3 Tested
Inhibition of human galactosidase after 30 mins by Kinase-GloTM assay
Assay data:9 Active, 2 Activity ≤ 1 µM, 13 Tested
Inhibition of human GALK1 up to 50 uM
Assay data:1 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
qHTS Validation Assay for Inhibitors of Human Galactokinase (GALK)
Assay data:3 Active, 1280 Tested
Confirmation Assay for Inhibitors of Human Galactokinase (GALK): SAR round 2
Assay data:8 Active, 25 Tested
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