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Inhibition of KMO (unknown origin)
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human liver mitochondrial KMO assessed as reduction in 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Inhibition of mouse liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis
Assay data:19 Active, 20 Activity ≤ 1 µM, 20 Tested
Inhibition of mouse liver mitochondrial KMO by measuring the 3-HK metabolite formation at 100 nM using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of human liver mitochondrial KMO at by measuring the 3-HK metabolite formation at 100 nM using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis relative to control
Assay data:1 Tested
Inhibition of human KMO using L-kynurenine as substrate incubated for 25 mins in presence of NADPH by microplate reader based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of mouse liver mitochondrial KMO using kynurenine as substrate by measuring the 3-HK formation preincubated for 5 mins followed by substrate addition and measured after 40 mins by LC-MS/MS analysis
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Competitive inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes assessed as dissociation rate constant using kynurenine as substrate measured after 1 hr by RapidFire high-throughput mass spectrometric analysis
Competitive inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes assessed as association rate constant using kynurenine as substrate measured after 1 hr by RapidFire high-throughput mass spectrometric analysis
Competitive inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured after 1 hr by RapidFire high-throughput mass spectrometric analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Competitive inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes assessed as dissociation half life using kynurenine as substrate measured after 1 hr by RapidFire high-throughput mass spectrometric analysis
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes assessed as dissociation half life using kynurenine as substrate measured after 1 hr by RapidFire high-throughput mass spectrometric analysis
Inhibition of rat KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of KMO in human primary hepatocytes using kynurenine as substrate measured after overnight incubation by LC-MS/MS analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of full length human KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis
Assay data:29 Active, 20 Activity ≤ 1 µM, 33 Tested
Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured after 1 hr by RapidFire high-throughput mass spectrometric analysis
Assay data:35 Active, 2 Activity ≤ 1 nM, 35 Activity ≤ 1 µM, 35 Tested
Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrate
Inhibition of rat KMO
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